Ichiro Takada

TL;DR: It is demonstrated that the infiltration of T cells into the brain, as well as the cytokines interleukin-23 (IL-23) and IL-17, have pivotal roles in the evolution of brain infarction and accompanying neurological deficits, and proposed that T lymphocytes, including γδT lymphocyte, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia.

TL;DR: The findings uncover a function for AhR as an atypical component of the ubiquitin ligase complex and demonstrate a non-genomic signalling pathway in which fat-soluble ligands regulate target-protein-selective degradation through a ubiquitIn ligasecomplex.

TL;DR: Wnt and PPARγ signaling in MSCs and the crosstalk between these pathways are summarized and future clinical application of this knowledge is speculated on as the basis of novel approaches for regeneration therapy.

TL;DR: The results suggest that the Wnt5a-Ror2 pathway is crucial for osteoclastogenesis in physiological and pathological environments and represents a therapeutic target for bone diseases, including arthritis.

TL;DR: It is suggested that the non-canonical Wnt signalling pathway suppresses PPAR-γ function through chromatin inactivation triggered by recruitment of a repressing histone methyltransferase, thus leading to an osteoblastic cell lineage from mesenchymal stem cells.