Roland Jacobs

TL;DR: MSC derived from different adult and neonatal tissues are compared with respect to their cell biological properties, surface marker expression and proliferative capacities and several MSC functions including in vitro and in vivo differentiation capacities within a variety of lineages and immune-modulatory properties are highlighted.

TL;DR: The clinical evaluation of 303 patients with the established diagnosis of CVID demonstrated a significant coincidence of granulomatous disease, autoimmune cytopenia, and splenomegaly, and an improved classification for CVID (EUROclass), separating patients with nearly absent B cells, and expansion of transitional or CD21(low) B cells.

TL;DR: The data support the view that CD56bright cells are specialized NK cells that regulate immunological response mechanisms rather by cytokine supply than by their cytotoxic potential.

TL;DR: It is demonstrated that adrenaline and noradrenaline modulate the migratory capacity of human NK cells via spleen-independent beta 2-adrenoceptor mechanism.

TL;DR: A primary immunodeficiency syndrome caused by loss-of-function mutations in the IL-21 receptor exhibits impaired B, T, and NK cell function.