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Ilka Lorenzen-Schmidt
Researcher at University of California, San Diego
Publications - 10
Citations - 877
Ilka Lorenzen-Schmidt is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 5, co-authored 5 publications receiving 836 citations. Previous affiliations of Ilka Lorenzen-Schmidt include University of California, Los Angeles.
Papers
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Journal ArticleDOI
The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy
Ralph Knöll,Masahiko Hoshijima,Hal M. Hoffman,Veronika Person,Ilka Lorenzen-Schmidt,Marie Louise Bang,Takeharu Hayashi,Nobuyuki Shiga,Hideo Yasukawa,Wolfgang Schaper,William J. McKenna,Mitsuhiro Yokoyama,Nicholas J. Schork,Jeffrey H. Omens,Andrew D. McCulloch,Akinori Kimura,Carol C. Gregorio,Wolfgang Poller,Jutta Schaper,Heinz P. Schultheiss,Kenneth R. Chien +20 more
TL;DR: It is proposed that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure.
Journal ArticleDOI
Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy
Ilka Lorenzen-Schmidt,Bruno D. Stuyvers,Henk E.D.J. ter Keurs,Moto-o Date,Masahiko Hoshijima,Kenneth R. Chien,Andrew D. McCulloch,Jeffrey H. Omens +7 more
TL;DR: The results indicate that the progression to heart failure in the MLPKO model may be driven by diastolic myocardial dysfunction and abnormal passive properties rather than systolic dysfunction.
Journal ArticleDOI
Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear.
Ilka Lorenzen-Schmidt,Geert W. Schmid-Schönbein,Wayne R. Giles,Andrew D. McCulloch,Shu Chien,Jeffrey H. Omens +5 more
TL;DR: The results suggest that the β-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism.
Journal ArticleDOI
Deficiency of Actinin-Associated LIM Protein Alters Regional Right Ventricular Function and Hypertrophic Remodeling
TL;DR: The results are consistent with the view that disruption of ALP is associated with diminished RV contractile function as well as altered hypertrophic remodeling.
Book ChapterDOI
Mechanotransduction in Cardiac Remodeling and Heart Failure
TL;DR: There is evidence that structural components of the myocardium such as the myocyte cytoskeleton play a critical role in mechanotransduction and are part of the mechanism behind cardiac remodeling and eventual heart failure.