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Ilya Korsunsky
Researcher at Brigham and Women's Hospital
Publications - 40
Citations - 4446
Ilya Korsunsky is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 14, co-authored 31 publications receiving 1792 citations. Previous affiliations of Ilya Korsunsky include University of Pittsburgh & New York University.
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Journal ArticleDOI
Fast, sensitive and accurate integration of single-cell data with Harmony.
Ilya Korsunsky,Nghia Millard,Jean Fan,Kamil Slowikowski,Fan Zhang,Kevin Wei,Yuriy Baglaenko,Michael B. Brenner,Po-Ru Loh,Po-Ru Loh,Po-Ru Loh,Soumya Raychaudhuri +11 more
TL;DR: Harmony, for the integration of single-cell transcriptomic data, identifies broad and fine-grained populations, scales to large datasets, and can integrate sequencing- and imaging-based data.
Journal ArticleDOI
Distinct fibroblast subsets drive inflammation and damage in arthritis.
Adam P. Croft,Joana Campos,Kathrin Jansen,Jason D. Turner,Jennifer L. Marshall,Moustafa Attar,Loriane Savary,Corinna Wehmeyer,Corinna Wehmeyer,Amy J. Naylor,Samuel Kemble,Jenefa Begum,Kerstin Dürholz,Kerstin Dürholz,Harris Perlman,Francesca Barone,Helen M. McGettrick,Douglas T. Fearon,Kevin Wei,Soumya Raychaudhuri,Ilya Korsunsky,Michael B. Brenner,Mark Coles,Stephen N. Sansom,Andrew Filer,Christopher D. Buckley +25 more
TL;DR: It is shown that deletion of fibroblast activation protein-α (FAPα)+ fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis.
Journal ArticleDOI
Notch signalling drives synovial fibroblast identity and arthritis pathology
Kevin Wei,Ilya Korsunsky,Jennifer L. Marshall,Anqi Gao,Gerald F. Watts,Triin Major,Adam P. Croft,Jordan Watts,Philip E. Blazar,Jeffrey K. Lange,Thomas S. Thornhill,Andrew Filer,Karim Raza,Laura T. Donlin,Christian W. Siebel,Christopher D. Buckley,Christopher D. Buckley,Soumya Raychaudhuri,Michael B. Brenner +18 more
TL;DR: The results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.
Journal ArticleDOI
BioNetGen 2.2: advances in rule-based modeling
Leonard A. Harris,Justin S. Hogg,Jose-Juan Tapia,John A. P. Sekar,Sanjana Gupta,Ilya Korsunsky,Arshi Arora,Dipak Barua,Robert P. Sheehan,James R. Faeder +9 more
TL;DR: Several new features for both model specification and simulation are reported on, discussing how they facilitate the construction, simulation and analysis of larger and more complex models than previously possible in BioNetGen.
Posted ContentDOI
Fast, sensitive, and accurate integration of single cell data with Harmony
Ilya Korsunsky,Jean Fan,Kamil Slowikowski,Fan Zhang,Kevin Wei,Yuriy Baglaenko,Michael B. Brenner,Po-Ru Loh,Soumya Raychaudhuri +8 more
TL;DR: Harmony is a fast and flexible general purpose integration algorithm that enables the identification of shared fine-grained subpopulations across a variety of experimental and biological conditions.