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In-Hyun Park
Researcher at Yale University
Publications - 137
Citations - 22758
In-Hyun Park is an academic researcher from Yale University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 57, co-authored 127 publications receiving 20714 citations. Previous affiliations of In-Hyun Park include Boston Children's Hospital & Brigham and Women's Hospital.
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Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) using retroviral vector with GFP.
TL;DR: The protocol to reprogram human fibroblast cells with the four reprogramming factors cloned into GFP-containing retroviral backbone is described and human iPSCs are generated under human ESC culture condition.
Posted ContentDOI
Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks
Yolpanhchana Lim,Jennifer E. Beane-Ebel,Yoshiaki Tanaka,Boting Ning,Christopher R. Husted,David C. Henderson,Yangfei Xiang,In-Hyun Park,Lindsay A. Farrer,Huiping Zhang +9 more
TL;DR: The authors investigated AUD-associated miRNA-mRNA regulatory networks in multiple brain regions by analyzing transcriptomic changes in two sets of postmortem brain tissue samples and ethanol-exposed human embryonic stem cell (hESC)-derived cortical interneurons.
Journal ArticleDOI
Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.
Jialin Sun,Sivan Osenberg,Austin Irwin,Li-hua Ma,Nigel Lee,Yangfei Xiang,Feng Li,Ying Wang,In-Hyun Park,Mirjana Maletic-Savatic,Nurit Ballas +10 more
TL;DR: In this paper , the authors show that mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most commonly Rett syndrome (RTT), and that these metabolic aberrations are likely mediated by dysfunctional mitochondria.
Journal ArticleDOI
Development of an inducible platform for intercellular protein delivery.
Richard Siller,Eric Dufour,Max Lycke,Ian Wilmut,Yong Wook Jung,In-Hyun Park,Gareth J. Sullivan,Gareth J. Sullivan +7 more
TL;DR: A novel platform, allowing the inducible export and uptake of a protein of interest, and addressing the issue of whether the observed uptake is an artefact of the fixation process or indeed genuine translocation is addressed.