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In-Hyun Park
Researcher at Yale University
Publications - 137
Citations - 22758
In-Hyun Park is an academic researcher from Yale University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 57, co-authored 127 publications receiving 20714 citations. Previous affiliations of In-Hyun Park include Boston Children's Hospital & Brigham and Women's Hospital.
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Journal ArticleDOI
Hematopoietic Development from Human Induced Pluripotent Stem Cells
Claudia Lengerke,Matthias Grauer,Nina I. Niebuhr,Tamara Riedt,Lothar Kanz,In-Hyun Park,George Q. Daley +6 more
TL;DR: The data show robust differentiation of iPS cells to mesoderm and to blood lineages, as shown by generation of CD34+CD45+ cells, hematopoietic colony activity, and gene expression data, and suggest conservation of blood patterning pathways between mouse and human hematoietIC development.
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Two methods for full-length RNA sequencing for low quantities of cells and single cells
Xinghua Pan,Russell E. Durrett,Haiying Zhu,Yoshiaki Tanaka,Yumei Li,Xiaoyuan Zi,Sadie L. Marjani,Ghia Euskirchen,Chao Ma,Chao Ma,Robert H. LaMotte,In-Hyun Park,Michael Snyder,Christopher E. Mason,Sherman M. Weissman +14 more
TL;DR: These protocols for the amplification and high-throughput sequencing of very small amounts of RNA for sequencing using procedures of either semirandom primed PCR or phi29 DNA polymerase-based DNA amplification, for the cDNA generated with oligo-dT and/or random oligonucleotide primers are reported.
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MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States
Pierre Neveu,Min Jeong Kye,Shuping Qi,David E. Buchholz,Dennis O. Clegg,Mustafa Sahin,In-Hyun Park,In-Hyun Park,Kwang-Soo Kim,George Q. Daley,Harley I. Kornblum,Boris I. Shraiman,Kenneth S. Kosik +12 more
TL;DR: This work profiled miRNA expression levels across 49 human cell lines, and found that the resulting miRNA profiles divided the iPSCs and hESCs examined into two distinct categories irrespective of the cell line origin.
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Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem Cells
Xin Ge,Yongming Ren,Oscar Bartulos,Min Young Lee,Zhichao Yue,Kun-Yong Kim,Wei Li,Peter J. Amos,Esra Cagavi Bozkulak,Amulya Iyer,Wei Zheng,Hongyu Zhao,Kathleen A. Martin,Darrell N. Kotton,George Tellides,In-Hyun Park,Lixia Yue,Yibing Qyang +17 more
TL;DR: SVAS iPSC-SMCs recapitulate key pathological features of patients with SVAS and may provide a promising strategy to study disease mechanisms and to develop novel therapies.
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Cell cycle adaptations of embryonic stem cells
Andrea Ballabeni,In-Hyun Park,Rui Zhao,Weiping Wang,Paul H. Lerou,George Q. Daley,Marc W. Kirschner +6 more
TL;DR: It is demonstrated that APC/C (anaphase-promoting complex/cyclosome) enzyme is active in ES cells but attenuated by high levels of the Emi1 (early mitotic inhibitor-1) protein, and despite the presence of high Cdk activity during the G1 phase, chromatin can be effectively licensed for DNA replication and fast entry into the S phase can still occur.