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In-Hyun Park
Researcher at Yale University
Publications - 137
Citations - 22758
In-Hyun Park is an academic researcher from Yale University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 57, co-authored 127 publications receiving 20714 citations. Previous affiliations of In-Hyun Park include Boston Children's Hospital & Brigham and Women's Hospital.
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Journal ArticleDOI
Live isolation of naïve ESCs via distinct glucose metabolism and stored glycogen.
Keun-Tae Kim,Jiyoung Oh,Seok-Tae Park,Seong M. Kim,Patterson Benjamin,In-Hyun Park,Kwang-Hoon Chun,Youngil Chang,Hyuk-Jin Cha +8 more
TL;DR: In this article , the authors found that intracellular glycogen led to specific reactivity to CDg4, a glycogen fluorescence sensor, in both human and mouse naïve embryonic stem cells.
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Gene-Correction Rescues Reprogramming of Fanconi Anemia Fibroblasts and Enables Hematopoietic Differentiation of FA Induced Pluripotent Stem Cells in Vitro and In Vivo
Lars Mueller,Michael D. Milsom,Chad E. Harris,Rutesh Vyas,Kristina Brumme,Kalindi Parmar,Axel Schambach,Elke Grassman,In-Hyun Park,London Wendy,Kelly Strait,Thorsten M. Schlaeger,Alex Devine,Alan D. D'Andrea,George Q. Daley,David A. Williams +15 more
TL;DR: A critical cell-intrinsic role of the FA pathway in reprogramming is confirmed, confirming that the reprograming resistance of FA cells is due to defective DNA repair and genomic instability.
Journal ArticleDOI
Telomere Elongation in Dyskeratosis Congenita Induced Pluripotent Stem Cells.
Suneet Agarwal,Yuin-Han Loh,Erin M. McLoughlin,Junjiu Huang,In-Hyun Park,Justine D. Miller,Hongguang Huo,Maja Okuka,Rosana Maria dos Reis,Sabine Loewer,David L. Keefe,Frederick D. Goldman,Aloysius J. Klingelhutz,Lin Liu,George Q. Daley +14 more
TL;DR: The results demonstrate that reprogramming restores self-renewal capacity in DC cells despite genetic lesions affecting telomerase, and suggest that strategies to enhance endogenous TERC expression may be feasible and therapeutically beneficial in DC patients.
Journal Article
Five Classic Articles in Somatic Cell Reprogramming
TL;DR: Five landmark papers that have laid the foundation for current efforts to apply somatic cell reprogramming in the clinic are reviewed.
Journal ArticleDOI
Human Down syndrome microglia are up for a synaptic feast.
F Ridvan Kiral,In-Hyun Park +1 more
TL;DR: Jin et al. as discussed by the authors showed that inhibiting interferon signaling rescues both developmental and tau-associated phenotypes, rendering it a potential therapeutic target for Down syndrome.