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In-Hyun Park
Researcher at Yale University
Publications - 137
Citations - 22758
In-Hyun Park is an academic researcher from Yale University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 57, co-authored 127 publications receiving 20714 citations. Previous affiliations of In-Hyun Park include Boston Children's Hospital & Brigham and Women's Hospital.
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Journal ArticleDOI
Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.
Yangfei Xiang,Yoshiaki Tanaka,Benjamin Patterson,Young-Jin Kang,Gubbi Govindaiah,Naomi Roselaar,Bilal Cakir,Kun-Yong Kim,Adam P. Lombroso,Sung Min Hwang,Mei Zhong,Edouard G. Stanley,Edouard G. Stanley,Edouard G. Stanley,Andrew G. Elefanty,Andrew G. Elefanty,Andrew G. Elefanty,Janice R. Naegele,Sang-Hun Lee,Sherman M. Weissman,In-Hyun Park +20 more
TL;DR: This study provides a platform for generating domain-specific brain organoids and modeling human interneuron migration and offers deeper insight into molecular dynamics during human brain development.
Journal ArticleDOI
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
M. Cristina Nostro,Farida Sarangi,Shinichiro Ogawa,Audrey Holtzinger,Barbara Corneo,Xueling Li,Suzanne J. Micallef,In-Hyun Park,Christina Basford,Michael B. Wheeler,George Q. Daley,Andrew G. Elefanty,Edouard G. Stanley,Gordon Keller +13 more
TL;DR: The temporal requirements for TGFβ family members and canonical WNT signaling are elucidated and it is shown that the duration of nodal/activin A signaling plays a pivotal role in establishing an appropriate definitive endoderm population for specification to the pancreatic lineage.
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Cardiomyocyte differentiation of human induced pluripotent stem cells.
TL;DR: In this article, the authors characterized the cardiomyocyte differentiation potential of human induced pluripotent stem (hiPS) cells and studied the molecular, structural, and functional properties of the generated hiPS-derived Cardiomyocytes.
Journal ArticleDOI
A role for Lin28 in primordial germ-cell development and germ-cell malignancy
Jason A. West,Srinivas R. Viswanathan,Akiko Yabuuchi,Kerianne Cunniff,Ayumu Takeuchi,In-Hyun Park,Julia E. Sero,Hao Zhu,Antonio R. Perez-Atayde,A. Lindsay Frazier,M. Azim Surani,George Q. Daley,George Q. Daley +12 more
TL;DR: It is shown that Blimp1 (also called Prdm1), a let-7 target and a master regulator of PGC specification, can rescue the effect of Lin28 deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during P GC specification.
Journal ArticleDOI
Regulatory networks define phenotypic classes of human stem cell lines
Franz-Josef Müller,Franz-Josef Müller,Louise C. Laurent,Louise C. Laurent,Dennis Kostka,Igor Ulitsky,Roy Williams,Christina Lu,In-Hyun Park,Mahendra S. Rao,Mahendra S. Rao,Ron Shamir,Philip H. Schwartz,Philip H. Schwartz,Nils Ole Schmidt,Jeanne F. Loring,Jeanne F. Loring +16 more
TL;DR: A database of global gene expression profiles that enables the classification of cultured human stem cells in the context of a wide variety of pluripotent, multipotent and differentiated cell types is created and analysis of this database offers a new strategy for classifying stem cells.