In-Hyun Park

TL;DR: This study demonstrated that a biocompatible PA-RGDS nanomatrix gel substantially improved long-term survival of hPSC-ECs in an ischemic environment and improved neovascularization effects of h PSCs via prolonged and unique angiogenic and vessel-forming properties.

TL;DR: It is found that MeCP2 mutations cause severe abnormalities in human interneurons (INs), and treatment with a BET inhibitor, JQ1, rescued the molecular and functional phenotypes of MeCP1 mutant INs, and suggest that targeting BRD4 could be a potential therapeutic opportunity for RTT.

TL;DR: Effects of cell cycle progression on the expression of lineage specific genes in precursor cells are revealed, and it is suggested that hematopoietic stress changes the balance of renewal and differentiation in these homeostatic cells.

TL;DR: By providing a limitless source of diseased stem cells that can be differentiated into various cell types in vitro, the repository of iPSC lines from patients with PIDs represents a unique resource to investigate the pathophysiology of hematopoietic and extrahematopoetic manifestations of these diseases and might assist in the development of novel therapeutic approaches based on gene correction.

TL;DR: The results demonstrate that the ASD-related gene MECp2 regulates the expression of components belonging to the dysbindin interactome and these molecular differences may contribute to synaptic phenotypes that characterize Mecp2 deficiencies and ASD.