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In-Hyun Park
Researcher at Yale University
Publications - 137
Citations - 22758
In-Hyun Park is an academic researcher from Yale University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 57, co-authored 127 publications receiving 20714 citations. Previous affiliations of In-Hyun Park include Boston Children's Hospital & Brigham and Women's Hospital.
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Journal ArticleDOI
A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells
Je-Hyuk Lee,In-Hyun Park,Yuan Gao,Jin Billy Li,Zhe Li,George Q. Daley,Kun Zhang,George M. Church +7 more
TL;DR: It is shown that the majority of detectable allele-specific expression loci remains consistent despite large changes in the cell type or the experimental condition following iPS reprogramming, except on the X-chromosome.
Journal ArticleDOI
Therapeutic potential of human induced pluripotent stem cells in experimental stroke.
Da Jeong Chang,Nayeon Lee,In-Hyun Park,In-Hyun Park,Chunggab Choi,Iksoo Jeon,Ji-Hye Kwon,Seung Hun Oh,Dong Ah Shin,Jeong Tae Do,Dong Ryul Lee,Hyunseung Lee,Hyeyoung Moon,Kwan Soo Hong,George Q. Daley,Jihwan Song +15 more
TL;DR: Animal MRI results indicated that the majority of contralaterally transplanted iPSC-derived NPCs migrated to the peri-infarct area, showing a pathotropism critical for tissue recovery.
Journal ArticleDOI
Human induced pluripotent stem cells and neurodegenerative disease: prospects for novel therapies
TL;DR: Recent progress in using induced pluripotent stem cell technology for modeling the progress and treatment of neurodegenerative diseases is summarized and evidence for future perspectives in this field is provided.
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Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells
Jung Bok Lee,Jung Bok Lee,Tamra E. Werbowetski-Ogilvie,Tamra E. Werbowetski-Ogilvie,Jong-Hee Lee,Jong-Hee Lee,Brendan A.S. McIntyre,Brendan A.S. McIntyre,Angelique Schnerch,Angelique Schnerch,Seok Ho Hong,Seok Ho Hong,In-Hyun Park,George Q. Daley,Irwin D. Bernstein,Mickie Bhatia,Mickie Bhatia +16 more
TL;DR: This study reveals a previously unappreciated role for the Notch pathway during early human hematopoiesis, whereby Notch signaling via HES1 represents a toggle switch of he matopoietic vs endothelial fate specification.
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Modelling human disease with pluripotent stem cells.
TL;DR: The current state of the art with regard to modelling diseases affecting the ectodermal, mesodermal and endodermal lineages is discussed, focussing on studies which have demonstrated a disease phenotype in the tissue of interest.