Ines Matos

TL;DR: The adjuvant action of poly IC requires a widespread innate type I IFN response that directly links antigen presentation by DCs to adaptive immunity, which is required in both marrow–derived and radioresistant host cells for adaptive responses.

TL;DR: It is shown that fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells, and the blood monocyte reservoir becomes the dominant presenting cell in response to select microbes, yielding DC- SIGN(+) cells with critical functions of DCs.

TL;DR: Protective immunity to protein vaccines is controlled by Flt3L-dependent classical LN-resident dendritic cells, and dampened by migratory dendrite cells.

TL;DR: Examination of DC capture of FITC from painted skin, DC isolation from skin explant culture, and from the skin of CCR7 knockout mice which accumulate migDC, demonstrate these cells are cutaneous residents.

TL;DR: It is found that LmSTI1a was superior for generation of IFN-γ-producing CD4(+) T cells, which correlated with higher protection of susceptible Balb/c mice to a challenge with L. major.