M
M. Paula Longhi
Researcher at Queen Mary University of London
Publications - 12
Citations - 1754
M. Paula Longhi is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Adipose tissue & Inflammation. The author has an hindex of 7, co-authored 11 publications receiving 1480 citations. Previous affiliations of M. Paula Longhi include Rockefeller University.
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Journal ArticleDOI
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant.
M. Paula Longhi,Christine Trumpfheller,Juliana Idoyaga,Marina Caskey,Ines Matos,Courtney Kluger,Andres M. Salazar,Marco Colonna,Ralph M. Steinman +8 more
TL;DR: The adjuvant action of poly IC requires a widespread innate type I IFN response that directly links antigen presentation by DCs to adaptive immunity, which is required in both marrow–derived and radioresistant host cells for adaptive responses.
Journal ArticleDOI
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas
Cheolho Cheong,Ines Matos,Jae-Hoon Choi,Durga Bhavani Dandamudi,Elina Shrestha,M. Paula Longhi,Kate L. Jeffrey,Robert M. Anthony,Courtney Kluger,Godwin Nchinda,Hyein Koh,Anthony Rodriguez,Juliana Idoyaga,Maggi Pack,Klara Velinzon,Chae Gyu Park,Ralph M. Steinman +16 more
TL;DR: It is shown that fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells, and the blood monocyte reservoir becomes the dominant presenting cell in response to select microbes, yielding DC- SIGN(+) cells with critical functions of DCs.
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The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.
Shinelle Menezes,Daisy Melandri,Giorgio Anselmi,Thibaut Perchet,Jakob Loschko,Juan Dubrot,Rajen Patel,Emmanuel L. Gautier,Stéphanie Hugues,M. Paula Longhi,Jake Y. Henry,Sergio A. Quezada,Grégoire Lauvau,Ana-Maria Lennon-Duménil,Enrique Gutiérrez-Martinez,Alain Bessis,Elisa Gomez-Perdiguero,Christian E. Jacome-Galarza,Hannah Garner,Frederic Geissmann,Rachel Golub,Michel C. Nussenzweig,Pierre Guermonprez +22 more
TL;DR: It is shown that naive monocytes are phenotypically heterogeneous and contain an NR4A1- and Flt3L-independent, CCR2-dependent, Flt 3+CD11c−MHCII+PU.1hi subset, which acted as a precursor for FcγRIII+PD-L2+CD209a+, GM-CSF-dependent moDCs but was distal from the DC lineage.
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Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation.
Austin R. Pantel,Angela Teixeira,Elias K. Haddad,Elizabeth G. Wood,Ralph M. Steinman,M. Paula Longhi +5 more
TL;DR: Type I IFN signaling is indispensable for the maturation of dendritic cells that are required to elicit an immune response, and it also controls a shift in cellular metabolism to meet the increased energy demands of DC maturation.
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Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
Claire E. Macdougall,Elizabeth G. Wood,Jakob Loschko,Valeria Scagliotti,Féaron C. Cassidy,Mark Robinson,Niklas Feldhahn,Leandro Castellano,Mathieu-Benoit Voisin,Federica M. Marelli-Berg,Carles Gaston-Massuet,Marika Charalambous,M. Paula Longhi +12 more
TL;DR: It is reported that conventional dendritic cells in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation, promoting an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance.