Inge C.L. van den Munckhof

TL;DR: Circulating monocytes of patients with symptomatic, but not asymptomatic, atherosclerosis have a pro-inflammatory phenotype and increased expression of glycolytic enzymes, associated with epigenetic remodeling at the level of histone methylation.

TL;DR: This study presents the largest metagenome-based association study on plasma metabolism and microbiome relevance to diet, inflammation, CVD risk, and cardiometabolic phenotypes in both population-based and clinical obesity cohorts and identified novel bacterial species and pathways associated to specific lipoprotein subclasses.

TL;DR: It is shown that natural selection on genetic variants in the PDE10A gene have increased spleen size in the Bajau, providing them with a larger reservoir of oxygenated red blood cells and evidence of strong selection specific to the Bjau on BDKRB2, a gene affecting the human diving reflex.

TL;DR: This study identifies several key species and pathways in IBD and obesity and provides evidence that altered microbial abundances in disease can influence their co-abundance relationship, which expands the current knowledge regarding microbial dysbiosis in disease.

TL;DR: Sex-specific pathways that influence inflammation in obesity are identified and different mechanisms of inflammatory dysregulation between women and men with obesity argue for sex-specific therapeutic strategies.