S
Siroon Bekkering
Researcher at Radboud University Nijmegen
Publications - 64
Citations - 3635
Siroon Bekkering is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Innate immune system & Medicine. The author has an hindex of 21, co-authored 44 publications receiving 2200 citations. Previous affiliations of Siroon Bekkering include Copenhagen University Hospital & University of Amsterdam.
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Journal ArticleDOI
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.
Rob J.W. Arts,Boris Novakovic,Rob ter Horst,Agostinho Carvalho,Siroon Bekkering,Ekta Lachmandas,Fernando Rodrigues,Ricardo Silvestre,Shih-Chin Cheng,Shih-Chin Cheng,Shuang-Yin Wang,Ehsan Habibi,Luís G. Gonçalves,Inês Mesquita,Cristina Cunha,Arjan van Laarhoven,Frank L. van de Veerdonk,David L. Williams,Jos W. M. van der Meer,Colin Logie,Luke A. J. O'Neill,Charles A. Dinarello,Charles A. Dinarello,Niels P. Riksen,Reinout van Crevel,Clary B. Clish,Richard A. Notebaart,Leo A. B. Joosten,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +31 more
TL;DR: Identification of the metabolic pathways leading to induction of trained immunity contributes to the understanding of innate immune memory and opens new therapeutic avenues.
Journal ArticleDOI
Metabolic Induction of Trained Immunity through the Mevalonate Pathway
Siroon Bekkering,Rob J.W. Arts,Boris Novakovic,Ioannis Kourtzelis,Charlotte D C C van der Heijden,Yang Li,Calin D. Popa,Rob ter Horst,Julia van Tuijl,Romana T. Netea-Maier,Frank L. van de Veerdonk,Triantafyllos Chavakis,Leo A. B. Joosten,Jos W. M. van der Meer,Henk Stunnenberg,Niels P. Riksen,Mihai G. Netea,Mihai G. Netea +17 more
TL;DR: It is reported that metabolic signals can induce trained immunity and the role of mevalonate in trained immunity contributes to the understanding of the pathophysiology of HIDS and identifies novel therapeutic targets for clinical conditions with excessive activation of trained immunity.
Journal ArticleDOI
Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes
Siroon Bekkering,Jessica Quintin,Leo A. B. Joosten,Jos W. M. van der Meer,Mihai G. Netea,Niels P. Riksen +5 more
TL;DR: Brief exposure of monocytes to a low concentration of oxLDL induces a long-lasting proatherogenic macrophage phenotype via epigenetic histone modifications, characterized by increased proinflammatory cytokine production and foam cell formation.
Journal ArticleDOI
Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans
Fleur M. van der Valk,Siroon Bekkering,Jeffrey Kroon,Calvin Yeang,Jan Van den Bossche,Jaap D. van Buul,Amir Ravandi,Aart J. Nederveen,Hein J. Verberne,Corey A. Scipione,Max Nieuwdorp,Leo A. B. Joosten,Mihai G. Netea,Marlys L. Koschinsky,Joseph L. Witztum,Sotirios Tsimikas,Niels P. Riksen,Erik S.G. Stroes +17 more
TL;DR: These findings demonstrate that Lp(a) induces monocyte trafficking to the arterial wall and mediates proinflammatory responses through its OxPL content, providing a novel mechanism by which Lp (a) mediates cardiovascular disease.
Journal ArticleDOI
Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Maziar Divangahi,Peter Aaby,Shabaana A. Khader,Luis B. Barreiro,Siroon Bekkering,Triantafyllos Chavakis,Reinout van Crevel,Nigel Curtis,Andrew R. DiNardo,Jorge Domínguez-Andrés,Raphael Duivenwoorden,Raphael Duivenwoorden,Stephanie Fanucchi,Zahi A. Fayad,Elaine Fuchs,Melanie Hamon,Kate L. Jeffrey,Nargis Khan,Leo A. B. Joosten,Eva Kaufmann,Eicke Latz,Giuseppe Matarese,Jos W. M. van der Meer,Musa M. Mhlanga,Simone J.C.F.M. Moorlag,Simone J.C.F.M. Moorlag,Willem J. M. Mulder,Willem J. M. Mulder,Shruti Naik,Boris Novakovic,Luke A. J. O'Neill,Jordi Ochando,Keiko Ozato,Niels P. Riksen,Robert W. Sauerwein,Edward R. Sherwood,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Michael H. Sieweke,Michael H. Sieweke,Christine Stabell Benn,Henk Stunnenberg,Joseph C. Sun,Joseph C. Sun,Frank L. van de Veerdonk,Sebastian Weis,David L. Williams,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea,Mihai G. Netea +52 more
TL;DR: A common framework is established that describes the experimental standards for defining trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects.