M
Marije Oosting
Researcher at Radboud University Nijmegen
Publications - 100
Citations - 10053
Marije Oosting is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Immune system & Cytokine. The author has an hindex of 42, co-authored 94 publications receiving 7335 citations. Previous affiliations of Marije Oosting include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
Rob J.W. Arts,Simone J.C.F.M. Moorlag,Boris Novakovic,Yang Li,Shuang-Yin Wang,Marije Oosting,Vinod Kumar,Ramnik J. Xavier,Cisca Wijmenga,Leo A. B. Joosten,Chantal B.E.M. Reusken,Christine Stabell Benn,Christine Stabell Benn,Peter Aaby,Peter Aaby,Marion Koopmans,Hendrik G. Stunnenberg,Reinout van Crevel,Mihai G. Netea,Mihai G. Netea +19 more
TL;DR: BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain, with a key role for IL-1β as a mediator of trained immunity responses.
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Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Hera Vlamakis,Martin Jaeger,Marije Oosting,Eric A. Franzosa,Eric A. Franzosa,Rob ter Horst,Trees Jansen,Liesbeth Jacobs,Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Jingyuan Fu,Jingyuan Fu,Leo A. B. Joosten,Alexandra Zhernakova,Curtis Huttenhower,Curtis Huttenhower,Cisca Wijmenga,Mihai G. Netea,Ramnik J. Xavier +22 more
TL;DR: Validation of two predicted host-microbial interactions reveal that TNFα and IFNγ production are associated with specific microbial metabolic pathways: palmitoleic acid metabolism andtryptophan degradation to tryptophol.
Journal ArticleDOI
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Anette Christ,Anette Christ,Patrick Günther,Mario A. Lauterbach,Peter Duewell,Debjani Biswas,Karin Pelka,Claus J. Scholz,Marije Oosting,Kristian Haendler,Kevin Baßler,Kathrin Klee,Jonas Schulte-Schrepping,Thomas Ulas,Simone J.C.F.M. Moorlag,Vinod Kumar,Min Hi Park,Min Hi Park,Leo A. B. Joosten,Laszlo Groh,Niels P. Riksen,Terje Espevik,Andreas Schlitzer,Yang Li,Michael L. Fitzgerald,Mihai G. Netea,Mihai G. Netea,Joachim L. Schultze,Joachim L. Schultze,Eicke Latz +29 more
TL;DR: NLRP3 mediates trained immunity following WD and could thereby mediate the potentially deleterious effects of trained immunity in inflammatory diseases.
Journal ArticleDOI
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases.
Serena Sanna,Natalie R. van Zuydam,Natalie R. van Zuydam,Anubha Mahajan,Alexander Kurilshikov,Arnau Vich Vila,Urmo Võsa,Zlatan Mujagic,Ad A.M. Masclee,Daisy Jonkers,Marije Oosting,Leo A. B. Joosten,Mihai G. Netea,Lude Franke,Alexandra Zhernakova,Jingyuan Fu,Cisca Wijmenga,Mark I. McCarthy,Mark I. McCarthy +18 more
TL;DR: Evidence of a causal effect of the gut microbiome on metabolic traits is shown and the use of MR is supported as a means to elucidate causal relationships from microbiome-wide association findings.
Journal ArticleDOI
The effect of host genetics on the gut microbiome
Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Ettje F. Tigchelaar,Zlatan Mujagic,Floris Imhann,Arnau Vich Vila,Patrick Deelen,Tommi Vatanen,Tommi Vatanen,Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Daria V. Zhernakova,Soesma A Jankipersadsing,Martin Jaeger,Marije Oosting,María Carmen Cenit,Ad A.M. Masclee,Morris A. Swertz,Yang Li,Vinod Kumar,Leo A. B. Joosten,Hermie J. M. Harmsen,Rinse K. Weersma,Lude Franke,Marten H. Hofker,Ramnik J. Xavier,Daisy Jonkers,Mihai G. Netea,Cisca Wijmenga,Jingyuan Fu,Alexandra Zhernakova +32 more
TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.