Inge Huitinga

TL;DR: It is indicated that hippocampal demyelination is frequent and extensive in MS and that anatomical localization, size, and inflammatory activity vary for different lesion types.

TL;DR: Significant increased CRF mRNA levels in the PVN of the depressed patients were found, accompanied by a significantly increased expression of four genes involved in the activation of CRF neurons, that is, CRFR1, estrogen receptor-α, AVPR1A and mineralocorticoid receptor, which raises the possibility that a disturbed balance in the production of receptors may contribute to theactivation of the HPA axis in depression.

TL;DR: A transcriptome database of cell-type enriched genes of astrocytes and microglia from adult mice is provided and insight is given into the differential gene signature of Astrocyte expression of genes involved in neuronal signaling remains high throughout age.

TL;DR: It is concluded that bone marrow derived macrophages play an important role in the pathogenesis of EAE via interactions with lymphocytes and the activation of resident microglia.

TL;DR: It is concluded that the human brain is surveilled by TRM cells, providing protection against neurotropic virus reactivation, whilst being under tight control of key immune checkpoint molecules.