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Ingrid M. Verhamme
Researcher at Vanderbilt University Medical Center
Publications - 46
Citations - 2199
Ingrid M. Verhamme is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Thrombin & Binding site. The author has an hindex of 26, co-authored 45 publications receiving 1937 citations. Previous affiliations of Ingrid M. Verhamme include Henry Ford Health System & Vanderbilt University.
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Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
Rainer W. Friedrich,Peter Panizzi,Pablo Fuentes-Prior,Klaus Richter,Ingrid M. Verhamme,Patricia J. Anderson,Shun Ichiro Kawabata,Robert Huber,Wolfram Bode,Paul E. Bock +9 more
TL;DR: These investigations demonstrate unambiguously the validity of the zymogen-activation mechanism known as ‘molecular sexuality’.
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Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates
Daniel A. Lawrence,David Ginsburg,Duane E. Day,Mitchell B. Berkenpas,Ingrid M. Verhamme,Jan-Olov Kvassman,Joseph D. Shore +6 more
TL;DR: This report shows that, upon association with a target protease, the serpin reactive-center loop (RCL) is cleaved resulting in formation of an acyl-enzyme intermediate, which is coupled to rapid movement of the RCL into the body of the protein bringing the inhibitor closer to its lowest free energy state.
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Exosites in the substrate specificity of blood coagulation reactions
TL;DR: The role of exosites as the major source of substrate specificity has stimulated development of exosite‐targeted anticoagulants for treatment of thrombosis.
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A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1 EVIDENCE FOR REACTIVE CENTER LOOP INSERTION AND ITS ROLE IN THE INHIBITORY MECHANISM
Joseph D. Shore,Duane E. Day,Ann Marie Francis-Chmura,Ingrid M. Verhamme,Jan Kvassman,Daniel A. Lawrence,David Ginsburg +6 more
TL;DR: Results demonstrate experimentally that complexation with proteases is presumably associated with loop insertion and that in the stable protease-PAI-1 complex the reactive center loop is cleaved and inserted into β sheet A and that this process is central to the inhibition mechanism.
Journal ArticleDOI
An update on factor XI structure and function.
Bassem M. Mohammed,Anton Matafonov,Ivan Ivanov,Mao-fu Sun,Qiufang Cheng,S. Kent Dickeson,Chan Li,David A. Sun,Ingrid M. Verhamme,Jonas Emsley,David Gailani +10 more
TL;DR: Current understanding of the biology and enzymology of FXI is reviewed, with an emphasis on structural features of the protein as they relate to protease function.