Showing papers in "Thrombosis Research in 2018"

TL;DR: Current understanding of the biology and enzymology of FXI is reviewed, with an emphasis on structural features of the protein as they relate to protease function.

TL;DR: VTE among hospitalized patients with cancer has increased significantly with a major impact on hospital mortality and costs and patients with major medical comorbidities and infectious complications are at particularly high risk.

TL;DR: Knowing the roles of neutrophils in thrombosis and inflammasome activation in the neutrophil may pave the road for novel anti-thrombotic agents in the future that do not affect hemostasis.

TL;DR: DOAC Stop reduces the false positivity for lupus anticoagulants observed in dilute Russells viper venom time (dRVVT) tests on DOAC-containing plasmas and could be useful for eliminating unwanted effects of DOACs on routine coagulation testing.

TL;DR: Molecular analysis of SERPINC1, the gene encoding antithrombin, may reveal new residues with functional or structural relevance and new mechanisms causing deficiency of this endogenous anticoagulant.

TL;DR: The plasma-derived products containing von Willebrand factor were recently suggested to determine a lower incidence of inhibitor development than recombinant products in PUPs, in the first 50 exposure days (EDs).

TL;DR: Current insight in the role of platelets as regulators of NET formation, both during infection and sterile inflammation are highlighted, to promote thrombosis in cancer patients.

TL;DR: VTE risk was increased in postmenopausal women with no previous thromboembolic events using oral HT, and further clinical trials are needed to sort out the impact of different types of progestin and different estrogen doses and administration routes on VTE risk.

TL;DR: The limited available evidence raises concern regarding embryo-foetal safety, with high incidence of miscarriages and a 4% rate of anomalies with the use of rivaroxaban.

TL;DR: CHAT, with its creation of a risk prediction model with prospective validation using the CHAT registry, is the first step in identifying safe and effective strategies to decrease HA-VTE in children by helping define the highest risk population for initial thromboprophylaxis efforts.

TL;DR: The current evidence is of low certainty but does not support an association between testosterone use and VTE in men.

TL;DR: The roles of tumor-educated platelets (TEPs) in the progression of cancer from primary tumors to secondary metastatic outbreaks is discussed.

TL;DR: Current applications of the "Khorana score" are described including identification of high- and low- risk patients, selecting and excluding patients for thromboprophylaxis and screening high-risk patients for early detection of VTE.

TL;DR: Antiplatelet drugs are promising agents that can improve the prognosis of sepsis patients and are expected to become a new line of treatment, however, further clinical studies are required for validation.

TL;DR: The increased NEU and N/L respectively have a strong correlation and precise predictability for carotid intimal and media thickness of atherosclerosis.

TL;DR: There is paucity of data on the efficacy and safety of DOACs in patients with cirrhosis, and this analysis suggests thatDOACs may be effective and safe for treatment of VTE, SVT, and AF in these patients.

TL;DR: This review will summarize the results of published studies and will focus on ongoing research and future directions of clotting activation bioproducts as biomarkers of cancer disease and progression.

TL;DR: The results suggest that the prescription of COC with the lowest possible dose of ethinylestradiol may help to avoid VTE cases among young, healthy women.

TL;DR: LMWH therapy for PVT in LC is effective, despite its effectiveness, there is a risk of hemorrhage, hence anticoagulation should be carefully considered, especially in patients with advanced LC and a history of variceal bleeding.

TL;DR: The biochemical identification of the target antigen epitope of aPL responsible of LA activity in the absence of aβ2GPI antibodies is identified together with the biological and clinical characteristics of these patients in comparison with classical triple positive patients.

TL;DR: In this article, the authors proposed that cancer-associated arterial thrombotic events (ATEs) are increasingly recognized in specific malignancies and in association with the expanding armamentarium of novel chemotherapeutic agents, including immunomodulatory drugs, vascular endothelial growth factor pathway inhibitors, tyrosine kinase inhibitors, and radiotherapy.

TL;DR: While preoperative anticoagulation delays surgery following fragility hip fractures, this delay was not found to be related to increased morbidity or mortality.

TL;DR: The role of podoplanin, a transmembrane glycoprotein with the ability to induce platelet activation via the platelet-receptor CLEC-2, is discussed, which could be a useful biomarker to identify patients at very high VTE risk.

TL;DR: The findings suggest a possible prevalent role of hypercoagulability in the pathogenesis of cancer-associated ischemic stroke and investigate independent factors associated with active cancer.

TL;DR: It is shown that a high EV-TF procoagulant activity as measured by the fibrin generation test is associated with an increased risk of VTE in cancer patients, in particular in those with pancreatic cancer.

TL;DR: Baseline P-selectin but not D-dimer levels predict recurrent VTE and may be a valuable addition to clinical prediction rules to select patients for more intensive therapy or closer observation.

TL;DR: In this paper, a wide variety of non-genetic and genetic factors have been shown to associate with increased risk for cerebral venous thrombosis (CVT), however, conclusions about their impact are often conflicting.

TL;DR: The detrimental effects of IFN on endothelial cell functions mediated with angiogenesis and fibrinolysis are demonstrated, which could potentially cause the loss of physiological endothelium thromboresistance and facilitate the development of vascular complications in a clinical setting.

TL;DR: Antithrombin effectively maintained microcirculation and vascular integrity by protecting the glycocalyx in a rat sepsis model by attenuating the derangement of the syndecan-1 lining.