Isaac Crespo

TL;DR: A computationally tractable, comprehensive molecular interaction map of Parkinson's disease that integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation is introduced.

TL;DR: A novel EMT core network integrating two fundamental negative feedback loops, miR203/SNAI1 and miR200/ZEB is proposed that could function as a switch controlling epithelial cell plasticity during differentiation and cancer progression.

TL;DR: In this paper, low-dose radiotherapy (LDRT) of murine tumors promotes T-cell infiltration and enables responsiveness to combinatorial immunotherapy in an interferon-dependent manner.

TL;DR: A computational method, without any preliminary selection of candidate genes, to identify reduced subsets of genes, which when perturbed can induce transitions between cellular phenotypes, and represents a useful framework to assist researchers in the field of cellular reprogramming to design experimental strategies.

TL;DR: This work introduces a method that generalizes the concept of transcription factor cross‐repression to systematically predict sets of genes, whose perturbations induce cellular transitions between any given pair of cell types, and is the first method that systematically makes these predictions without prior knowledge of potential candidate genes and pathways involved.