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Isaac J. Rondon
Publications - 7
Citations - 432
Isaac J. Rondon is an academic researcher. The author has contributed to research in topics: Ligand (biochemistry) & Complementarity determining region. The author has an hindex of 5, co-authored 7 publications receiving 414 citations.
Papers
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Journal ArticleDOI
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
Rene Hoet,Edward H. Cohen,Rachel Baribault Kent,Kristin L. Rookey,Sonia Schoonbroodt,Shannon Hogan,Louise Rem,Nicolas Frans,Marc Daukandt,Henk Pieters,Rob van Hegelsom,Nicole Coolen-van Neer,Nastri Horacio G,Isaac J. Rondon,Jennifer A. Leeds,Simon E. Hufton,Lili Huang,Irina Kashin,Mary Devlin,Guannan Kuang,Mieke Steukers,Malini Viswanathan,Andrew E. Nixon,Daniel J. Sexton,Hennie R. Hoogenboom,Robert Charles Ladner +25 more
TL;DR: The construction of human Fab libraries having a unique combination of immunoglobulin sequences captured from human donors and synthetic diversity in key antigen contact sites in heavy-chain complementarity-determining regions 1 and 2 are reported.
Patent
Cd44-binding ligands
TL;DR: In this article, the CD44-binding proteins, including CD44 binding antibodies, antibody fragments, and pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such proteins are described.
Journal ArticleDOI
Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1
Lili Huang,Motomu Shimaoka,Isaac J. Rondon,Illa Roy,Qing Chang,Melody Po,Daniel T. Dransfield,Robert Charles Ladner,Albert S.B. Edge,Azucena Salas,Clive R. Wood,Timothy A. Springer,Edward H. Cohen +12 more
TL;DR: Results indicate that specifically targeting the HA I domain is sufficient to inhibit LFA‐1‐mediated, adhesive functions, and represents a therapeutic candidate for treatment of inflammatory and autoimmune diseases.
Patent
Conformation specific antibodies
TL;DR: In this article, the binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g. relative to a non-activated conformation of LFA-1, are disclosed.
Patent
Binding peptides for carcinoembryonic antigen (CEA)
TL;DR: In this article, isolated polypeptides capable of binding CEA, which is overexpressed in adenocarcinomas of endodermally derived digestive system epithelia and fetal colon, are disclosed.