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Anastasia A. Gulyaeva
Researcher at Leiden University Medical Center
Publications - 15
Citations - 7159
Anastasia A. Gulyaeva is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Genome & Coronavirus. The author has an hindex of 9, co-authored 14 publications receiving 4931 citations. Previous affiliations of Anastasia A. Gulyaeva include Leiden University.
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Journal ArticleDOI
The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
Alexander E. Gorbalenya,Susan C. Baker,Ralph S. Baric,Raoul J. de Groot,Christian Drosten,Anastasia A. Gulyaeva,Bart L. Haagmans,Chris Lauber,Andrey M. Leontovich,Benjamin W. Neuman,Dmitry Penzar,Stanley Perlman,Leo L.M. Poon,Dmitry V. Samborskiy,Igor A. Sidorov,Isabel Sola,John Ziebuhr +16 more
TL;DR: The independent zoonotic transmission of SARS-CoV and SARS -CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance.
Posted ContentDOI
Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group
Alexander E. Gorbalenya,Alexander E. Gorbalenya,Susan C. Baker,Ralph S. Baric,Raoul J. de Groot,Christian Drosten,Anastasia A. Gulyaeva,Bart L. Haagmans,Chris Lauber,Andrey M. Leontovich,Benjamin W. Neuman,Dmitry Penzar,Stanley Perlman,Leo L.M. Poon,Dmitry V. Samborskiy,Igor A. Sidorov,Isabel Solá Gurpegui,John Ziebuhr +17 more
TL;DR: The Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses assessed the novelty of the human pathogen tentatively named 2019-nCoV and formally recognizes this virus as a sister to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses
Kathleen C. Lehmann,Anastasia A. Gulyaeva,Jessika C. Zevenhoven-Dobbe,George M.C. Janssen,Mark Ruben,Hermen S. Overkleeft,Peter A. van Veelen,Dmitry V. Samborskiy,Alexander A. Kravchenko,Andrey M. Leontovich,Igor A. Sidorov,Eric J. Snijder,Clara C. Posthuma,Alexander E. Gorbalenya,Alexander E. Gorbalenya +14 more
TL;DR: Bioinformatics analysis of non-structural protein 9 of the arterivirus equine arteritis virus revealed a nidoviral signature domain (genetic marker) that is N-terminally adjacent to the RdRp and has no apparent homologs elsewhere, and is proposed to have nucleotidylation activity.
Journal ArticleDOI
A planarian nidovirus expands the limits of RNA genome size.
Amir Saberi,Anastasia A. Gulyaeva,John L. Brubacher,Phillip A. Newmark,Alexander E. Gorbalenya,Alexander E. Gorbalenya +5 more
TL;DR: The evolutionary analysis suggests that PSCNV diverged early from multi-ORF nidoviruses, and acquired additional genes, including those typical of large DNA viruses or hosts, e.g. Ankyrin and Fibronectin type II, which might modulate virus-host interactions.
Journal ArticleDOI
Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.
Heiko Slanina,Ramakanth Madhugiri,Ganesh Bylapudi,Karin Schultheiß,Nadja Karl,Anastasia A. Gulyaeva,Alexander E. Gorbalenya,Alexander E. Gorbalenya,Uwe Linne,John Ziebuhr +9 more
TL;DR: In this article, it was shown that the NiRAN-RdRp has Mn2+-dependent NMPylation activity that catalyzes the transfer of a single NMP to the cognate nsp9 by forming a phosphoramidate bond with the primary amine at the nsp 9 N terminus (N3825).