Isabela Werneck da Cunha

TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.

TL;DR: It is shown that P2X7 receptor promotes T helper 1 (Th1) cell differentiation to the detriment of follicular T helper (Tfh) cells during blood-stage Plasmodium chabaudi malaria, providing a new insight into malaria immunology.

TL;DR: Results provided molecular evidence of the recapitulation of the embryonic kidney by WT as well as involvement of the Wnt pathway in the earliest events of WT onset.

TL;DR: In this paper, the gene expression profile in epithelial cells during breast ductal carcinoma (DC) progression has been shown to occur mainly between pure DCIS to the in situ component of a lesion with coexisting invasive DCIS-IDC implying that the molecular program for invasion is already established in the preinvasive lesion.

TL;DR: In this article, the authors provided a review of molecular pathology principles as well as the current state of the molecular pathology in Brazil. And they proposed practical and actionable recommendations for the implementation of molecular pathologists throughout the country in order to increase awareness of the importance molecular pathology.