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Patricia Cristina Baleeiro Beltrão-Braga
Researcher at University of São Paulo
Publications - 39
Citations - 2318
Patricia Cristina Baleeiro Beltrão-Braga is an academic researcher from University of São Paulo. The author has contributed to research in topics: Zika virus & Induced pluripotent stem cell. The author has an hindex of 17, co-authored 38 publications receiving 1875 citations. Previous affiliations of Patricia Cristina Baleeiro Beltrão-Braga include University of California, San Diego & Federal University of São Paulo.
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Journal ArticleDOI
The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
Journal ArticleDOI
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
Maria C. Marchetto,Haim Belinson,Yuan Tian,Beatriz C.G. Freitas,Chen Fu,Krishna C. Vadodaria,Patricia Cristina Baleeiro Beltrão-Braga,Patricia Cristina Baleeiro Beltrão-Braga,Cleber A. Trujillo,Ana P.D. Mendes,Krishnan Padmanabhan,Yanelli Nunez,Yanelli Nunez,Jing Ou,Himanish Ghosh,Rebecca Wright,Kristen J. Brennand,Karen Pierce,Lawrence F. Eichenfield,Tiziano Pramparo,Lisa T. Eyler,Cynthia Carter Barnes,Eric Courchesne,Daniel H. Geschwind,Fred H. Gage,Anthony Wynshaw-Boris,Anthony Wynshaw-Boris,Alysson R. Muotri +27 more
TL;DR: This work reprogrammed fibroblasts to generate induced pluripotent stem cells, neural progenitor cells and neurons from ASD individuals with early brain overgrowth and non-ASD controls with normal brain size and revealed a potential cellular mechanism for the therapeutic effect of IGF-1.
Journal ArticleDOI
Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells.
Fabiele Baldino Russo,Beatriz C.G. Freitas,Graciela Conceição Pignatari,Isabella Rodrigues Fernandes,Jonathan Sebat,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +6 more
TL;DR: The contribution of astrocytes to neuronal phenotype is revealed and previous studies linking interleukin-6 and autism are confirmed, suggesting potential novel therapeutic pathways for a subtype of individuals with ASD.
Journal ArticleDOI
Feeder-free derivation of induced pluripotent stem cells from human immature dental pulp stem cells.
Patricia Cristina Baleeiro Beltrão-Braga,Patricia Cristina Baleeiro Beltrão-Braga,Graciela Conceição Pignatari,Graciela Conceição Pignatari,Paulo César Maiorka,Nélio A. J. Oliveira,Nelson F. Lizier,Nelson F. Lizier,Cristiane Valverde Wenceslau,Cristiane Valverde Wenceslau,Maria Angélica Miglino,Maria Angélica Miglino,Alysson R. Muotri,Irina Kerkis,Irina Kerkis +14 more
TL;DR: It is demonstrated that human immature dental pulp stem cells (hIDPSCs)-iPSCs offer an advantageous cell system for future cell therapy and basic studies, particularly as a model for pediatric developmental disorders.
Journal ArticleDOI
Zika infection and the development of neurological defects.
TL;DR: The mechanisms underlying ZikV infection in the central nervous system require further investigation particularly as there are currently no treatments or vaccines against ZIKV infection.