B
Beatriz C.G. Freitas
Researcher at University of California, San Diego
Publications - 23
Citations - 2585
Beatriz C.G. Freitas is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Induced pluripotent stem cell & Neural stem cell. The author has an hindex of 16, co-authored 21 publications receiving 2171 citations. Previous affiliations of Beatriz C.G. Freitas include University of São Paulo & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
Journal ArticleDOI
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
Maria C. Marchetto,Haim Belinson,Yuan Tian,Beatriz C.G. Freitas,Chen Fu,Krishna C. Vadodaria,Patricia Cristina Baleeiro Beltrão-Braga,Patricia Cristina Baleeiro Beltrão-Braga,Cleber A. Trujillo,Ana P.D. Mendes,Krishnan Padmanabhan,Yanelli Nunez,Yanelli Nunez,Jing Ou,Himanish Ghosh,Rebecca Wright,Kristen J. Brennand,Karen Pierce,Lawrence F. Eichenfield,Tiziano Pramparo,Lisa T. Eyler,Cynthia Carter Barnes,Eric Courchesne,Daniel H. Geschwind,Fred H. Gage,Anthony Wynshaw-Boris,Anthony Wynshaw-Boris,Alysson R. Muotri +27 more
TL;DR: This work reprogrammed fibroblasts to generate induced pluripotent stem cells, neural progenitor cells and neurons from ASD individuals with early brain overgrowth and non-ASD controls with normal brain size and revealed a potential cellular mechanism for the therapeutic effect of IGF-1.
Journal ArticleDOI
A human neurodevelopmental model for Williams syndrome
Thanathom Chailangkarn,Thanathom Chailangkarn,Cleber A. Trujillo,Beatriz C.G. Freitas,Branka Hrvoj-Mihic,Roberto H. Herai,Roberto H. Herai,Diana X. Yu,Timothy T. Brown,Maria C. Marchetto,Cedric Bardy,Cedric Bardy,Lauren McHenry,Lisa Stefanacci,Anna Järvinen,Yvonne M. Searcy,Michelle DeWitt,Wenny Wong,Philip Lai,M. Colin Ard,Kari L. Hanson,Sarah Romero,Bob Jacobs,Anders M. Dale,Li Dai,Julie R. Korenberg,Fred H. Gage,Fred H. Gage,Ursula Bellugi,Eric Halgren,Katerina Semendeferi,Alysson R. Muotri +31 more
TL;DR: A model of human induced pluripotent stem cells fills the current knowledge gap in the cellular biology of Williams syndrome and could lead to further insights into the molecular mechanism underlying the disorder and the human social brain.
Journal ArticleDOI
Paracrine signaling by glial cell–derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells
Beatriz C.G. Freitas,Balázs Gereben,Melany Castillo,Imre Kalló,Anikó Zeöld,Péter Egri,Zsolt Liposits,Ann Marie Zavacki,Rui M. B. Maciel,Sungro Jo,Praful S. Singru,Edith Sánchez,Ronald M. Lechan,Antonio C. Bianco +13 more
TL;DR: This study presents what it is believed to be the first direct evidence for a paracrine loop linking glial D2 activity to TH receptors in neurons, thereby identifying deiodinases as potential control points for the regulation of TH signaling in the brain during health and disease.
Journal ArticleDOI
Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction
Zhen Ning Zhang,Beatriz C.G. Freitas,Beatriz C.G. Freitas,Hao Qian,Jacques Lux,Allan Acab,Allan Acab,Cleber A. Trujillo,Cleber A. Trujillo,Roberto H. Herai,Roberto H. Herai,Viet Anh Nguyen Huu,Jessica H. Wen,Shivanjali Joshi-Barr,Jerome V. Karpiak,Jerome V. Karpiak,Adam J. Engler,Xiang-Dong Fu,Alysson R. Muotri,Alysson R. Muotri,Adah Almutairi +20 more
TL;DR: A previously unidentified layered 3D culture system to assay migration and maturation of human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) and reveal a genotype-specific effect of methyl-CpG-binding protein-2 (MeCP2) dysfunction on iPSC-derived neuronal migration andmaturation in 3D layered hydrogels is reported.