Carla Longo de Freitas

TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.

TL;DR: This review provides a brief discussion of these main clinical aspects of the CZS, correlating them with the experimental animal models described so far, and concludes that the virus is responsible for the so called congenital Zika syndrome.

TL;DR: In this paper, the authors demonstrate that there is a correlation between ZIKV neurological complications with higher Gas6 levels and the downregulation of genes associated with anti-viral response, as type I IFN due to Socs1 upregulation.

TL;DR: In this paper, the authors demonstrate high Gas6 levels in the serum of patients with neurological complications which correlated with downregulation of genes associated with the type I IFN responses as consequence of Socs1 upregulation.

TL;DR: The results of the present study demonstrate the immunogenicity and protective properties of a dengue vaccine delivered through the TC route and offer perspectives for future clinical applications.