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Isabella Rodrigues Fernandes
Researcher at University of California, San Diego
Publications - 20
Citations - 1638
Isabella Rodrigues Fernandes is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Zika virus & Rett syndrome. The author has an hindex of 11, co-authored 19 publications receiving 1342 citations. Previous affiliations of Isabella Rodrigues Fernandes include University of São Paulo.
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The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
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Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells.
Fabiele Baldino Russo,Beatriz C.G. Freitas,Graciela Conceição Pignatari,Isabella Rodrigues Fernandes,Jonathan Sebat,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +6 more
TL;DR: The contribution of astrocytes to neuronal phenotype is revealed and previous studies linking interleukin-6 and autism are confirmed, suggesting potential novel therapeutic pathways for a subtype of individuals with ASD.
Journal ArticleDOI
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis
Sergey A. Shiryaev,Pinar Mesci,Antonella Pinto,Isabella Rodrigues Fernandes,Nicholas Sheets,Sujan Shresta,Chen Farhy,Chun-Teng Huang,Alex Y. Strongin,Alysson R. Muotri,Alexey V. Terskikh +10 more
TL;DR: It is demonstrated that the common anti-malaria drug chloroquine (CQ) extends the lifespan of ZIKV-infected interferon signalling-deficient AG129 mice, and it is suggested that CQ could be considered for the treatment and prophylaxis of ZikV.
Journal ArticleDOI
Blocking Zika virus vertical transmission.
Pinar Mesci,Angela Macia,Spencer M. Moore,Sergey A. Shiryaev,Antonella Pinto,Chun-Teng Huang,Leon Tejwani,Isabella Rodrigues Fernandes,Nicole A. Suarez,Matthew J. Kolar,Sandro Montefusco,Scott C. Rosenberg,Scott C. Rosenberg,Roberto H. Herai,Fernanda R. Cugola,Fabiele Baldino Russo,Nicholas Sheets,Alan Saghatelian,Sujan Shresta,Jeremiah D. Momper,Jair L. Siqueira-Neto,Kevin D. Corbett,Patricia Cristina Baleeiro Beltrão-Braga,Alexey V. Terskikh,Alysson R. Muotri +24 more
TL;DR: SOF-mediated sparing of human neural cell types from ZIKV-mediated cell death in vitro and reduced viral burden in vivo in animal models of chronic infection and vertical transmission are confirmed, strengthening the growing body of evidence for SOF anti-ZIKV activity.
Journal ArticleDOI
Modeling neuro-immune interactions during Zika virus infection
Pinar Mesci,Angela Macia,Christopher N. LaRock,Leon Tejwani,Isabella Rodrigues Fernandes,Nicole A. Suarez,Paolo Marinho de Andrade Zanotto,Patricia Cristina Baleeiro Beltrão-Braga,Victor Nizet,Alysson R. Muotri +9 more
TL;DR: Using the model, it is shown that Sofosbuvir, an FDA-approved drug for Hepatitis C, blocked viral infection in NPCs and therefore the transmission of the virus from microglia to NPCs, providing a new tool for studying neuro-immune interactions and a platform to test new therapeutic drugs.