P
Paolo Marinho de Andrade Zanotto
Researcher at University of São Paulo
Publications - 137
Citations - 7393
Paolo Marinho de Andrade Zanotto is an academic researcher from University of São Paulo. The author has contributed to research in topics: Zika virus & Gene. The author has an hindex of 34, co-authored 131 publications receiving 6606 citations. Previous affiliations of Paolo Marinho de Andrade Zanotto include Federal University of São Paulo & University of Florida.
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The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
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Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
Oumar Faye,Caio César de Melo Freire,Atila Iamarino,Ousmane Faye,Juliana Velasco Castro de Oliveira,Mawlouth Diallo,Paolo Marinho de Andrade Zanotto,Amadou A. Sall +7 more
TL;DR: Evidence is presented that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector.
Journal ArticleDOI
Vaccine protection against Zika virus from Brazil
Rafael A. Larocca,Peter Abbink,Jean Pierre Schatzmann Peron,Paolo Marinho de Andrade Zanotto,M. Justin Iampietro,Alexander Badamchi-Zadeh,Michael R. Boyd,David Ng’ang’a,Marinela Kirilova,Ramya Nityanandam,Noe B. Mercado,Zhenfeng Li,Edward T. Moseley,Christine A. Bricault,Erica N. Borducchi,Patricia B. Giglio,David Jetton,George H. Neubauer,Joseph P. Nkolola,Lori F. Maxfield,Rafael De La Barrera,Richard G. Jarman,Kenneth H. Eckels,Nelson L. Michael,Stephen J. Thomas,Dan H. Barouch,Dan H. Barouch +26 more
TL;DR: It is demonstrated that protection against ZIKV challenge can be achieved by single-shot subunit and inactivated virus vaccines in mice and that Env-specific antibody titers represent key immunologic correlates of protection.
Journal ArticleDOI
Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Peter Abbink,Rafael A. Larocca,Rafael De La Barrera,Christine A. Bricault,Edward T. Moseley,Michael R. Boyd,Marinela Kirilova,Zhenfeng Li,David Ng’ang’a,Ovini Nanayakkara,Ramya Nityanandam,Noe B. Mercado,Erica N. Borducchi,Arshi Agarwal,Amanda L. Brinkman,Crystal Cabral,Abishek Chandrashekar,Patricia B. Giglio,David Jetton,Jessica Jimenez,Benjamin C. Lee,Shanell Mojta,Katherine Molloy,Mayuri Shetty,George H. Neubauer,Kathryn E. Stephenson,Jean Pierre Schatzmann Peron,Paolo Marinho de Andrade Zanotto,Johnathan Misamore,Brad Finneyfrock,Mark G. Lewis,Galit Alter,Kayvon Modjarrad,Richard G. Jarman,Kenneth H. Eckels,Nelson L. Michael,Stephen J. Thomas,Dan H. Barouch,Dan H. Barouch +38 more
TL;DR: It is demonstrated that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys, and these data support the rapid clinical development of ZikV vaccines for humans.
Journal ArticleDOI
Population dynamics of flaviviruses revealed by molecular phylogenies
Paolo Marinho de Andrade Zanotto,Ernest A. Gould,George F. Gao,Paul H. Harvey,Edward C. Holmes +4 more
TL;DR: An analysis of phylogenetic tree structure reveals a continual and asymmetric branching process in the tick-borne flaviviruses, compared with an explosive radiation in the last 200 years in viruses transmitted by mosquitoes.