Israel Hernandez

TL;DR: Low-density lipoprotein receptor-related protein 1 (LRP1) is shown to be a critical determinant of tau propagation in the brain, and therefore a potential target for the treatment of diseases that involve tau spread and aggregation.

TL;DR: It is reported that tau protein, the primary constituent of Alzheimer neurofibrillary tangles, can form liquid droplets and therefore has the necessary biophysical properties to undergo liquid-liquid phase separation (LLPS) in cells and suggests that the droplet state can incubate tau and predispose the protein toward the formation of insoluble fibrils.

TL;DR: Significant differences between in vitro models are observed, including hiPSC-derived neural progenitors from multiple laboratories, and a machine learning approach called CoNTExT is developed and validated that identifies the developmental maturity and regional identity of in-vItro models.

TL;DR: Silencing of CDK5 reduces the phosphorylation of tau in primary neuronal cultures and in the brain of wild-type C57BL/6 mice, and the knockdown strongly decreased the number of neurofibrillary tangles in the hippocampi of triple-transgenic mice.

TL;DR: It is proposed that ubiquitinated Tau inclusions arise due to shunting of Tau degradation toward a less efficient ubiquitin-dependent pathway.