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Israt S. Alam
Researcher at Stanford University
Publications - 53
Citations - 1876
Israt S. Alam is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & In vivo. The author has an hindex of 16, co-authored 46 publications receiving 1381 citations. Previous affiliations of Israt S. Alam include Hammersmith Hospital & Pasteur Institute.
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Journal ArticleDOI
Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
Zachary T. Schug,Barrie Peck,Dylan T. Jones,Qifeng Zhang,Shaun E. Grosskurth,Israt S. Alam,Louise Goodwin,Elizabeth Smethurst,Susan M. Mason,Karen Blyth,Lynn McGarry,Daniel James,Emma Shanks,Gabriela Kalna,Rebecca E. Saunders,Ming Jiang,Michael Howell,Francois Lassailly,May Zaw Thin,Bradley Spencer-Dene,Gordon Stamp,Niels J. F. van den Broek,Gillian M. Mackay,Vinay Bulusu,Jurre J. Kamphorst,Saverio Tardito,David P. Strachan,Adrian L. Harris,Eric O. Aboagye,Susan E. Critchlow,Michael J.O. Wakelam,Almut Schulze,Eyal Gottlieb +32 more
TL;DR: A critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment is concluded, indicating a critical role in the growth of cancer cell growth under low-oxygen and lipid-depleted conditions.
Journal ArticleDOI
Eradication of spontaneous malignancy by local immunotherapy
Idit Sagiv-Barfi,Debra K. Czerwinski,Shoshana Levy,Israt S. Alam,Aaron T. Mayer,Sanjiv S. Gambhir,Ronald Levy +6 more
TL;DR: A combination therapy in multiple types of mouse cancer models that could provide sustainable antitumor immunity and led to shrinkage of distant tumors and long-term survival of the animals, even in a stringent spontaneous tumor model is investigated.
Journal ArticleDOI
Imaging activated T cells predicts response to cancer vaccines
Israt S. Alam,Aaron T. Mayer,Idit Sagiv-Barfi,Kezheng Wang,Ophir Vermesh,Debra K. Czerwinski,Emily M. Johnson,Michelle L. James,Ronald Levy,Sanjiv S. Gambhir +9 more
TL;DR: A PET tracer that enabled noninvasive and longitudinal imaging of OX40, a cell-surface marker of T cell activation, indicates that 64Cu-DOTA-AbOX40 is a promising candidate for monitoring clinical cancer immunotherapy strategies.
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A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.
John A. Ronald,Byung Su Kim,Gayatri Gowrishankar,Mohammad Namavari,Israt S. Alam,Aloma L. D'Souza,Hidekazu Nishikii,Hui Yen Chuang,Hui Yen Chuang,Ohad Ilovich,Chih Feng Lin,Chih Feng Lin,Robert Reeves,Adam J. Shuhendler,Aileen Hoehne,Carmel T. Chan,Jeanette Baker,Shahriar S. Yaghoubi,Henry F. VanBrocklin,Randall A. Hawkins,Benjamin L. Franc,Salma Jivan,James B. Slater,Emily Verdin,Kenneth T. Gao,Jonathan Benjamin,Robert S. Negrin,Sanjiv S. Gambhir +27 more
TL;DR: A novel PET radiotracer, 2'-deoxy-2'-[ 18F]fluoro-9-β-D-arabinofuranosylguanine ([18F]F-AraG), targeted toward two salvage kinase pathways preferentially accumulates in activated primary T cells, showing great potential for early aGVHD diagnosis, enabling timely treatments and improved patient outcomes.
Journal ArticleDOI
An intravascular magnetic wire for the high-throughput retrieval of circulating tumour cells in vivo
Ophir Vermesh,Amin Aalipour,T. Jessie Ge,T. Jessie Ge,Yamil Saenz,Yue Guo,Israt S. Alam,Seung-min Park,Charlie N. Adelson,Yoshiaki Mitsutake,Jose G. Vilches-Moure,Elias Godoy,Michael Bachmann,Chin Chun Ooi,Jennifer Lyons,Kerstin Mueller,Hamed Arami,Alfredo Green,Edward I. Solomon,Shan X. Wang,Sanjiv S. Gambhir +20 more
TL;DR: A flexible magnetic wire is reported that can retrieve rare biomarkers from the subject’s blood in vivo at a much higher yield and improves cell capture in anaesthetized pigs by up to two orders of magnitude with respect to a standard blood draw.