Louise Goodwin

TL;DR: A critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment is concluded, indicating a critical role in the growth of cancer cell growth under low-oxygen and lipid-depleted conditions.

TL;DR: Progress using fragment-based lead generation (FBLG), assisted by X-ray crystallography to develop small molecule LDHA inhibitors, which were identified through NMR and SPR screening and optimized into lead compounds with nanomolar binding affinities via fragment linking.

TL;DR: It is concluded that the role of MTH1 in carcinogenesis and utility of its inhibition is yet to be established and the difference between the responses of the highly selective inhibitors and published tool compounds suggests that the effect reported for the latter may be due to off-target cytotoxic effects.

TL;DR: It is demonstrated that AZD0156 impedes the repair of olaparib-induced DNA damage, resulting in elevated DNA double-strand break signaling, cell-cycle arrest, and apoptosis, as measured by phosphorylation of ATM substrates.

TL;DR: It is demonstrated that DYRK1B also undergoes trans-autophosphorylation on serine-421 (S421) in vitro and in cells and that this site contributes to DYRk1B kinase activity, uncovering new links between two kinases involved in cell fate decisions.