R
Rebecca E. Saunders
Researcher at Francis Crick Institute
Publications - 30
Citations - 2373
Rebecca E. Saunders is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Factor H & Hippo signaling pathway. The author has an hindex of 18, co-authored 29 publications receiving 2010 citations. Previous affiliations of Rebecca E. Saunders include Lincoln's Inn & London Research Institute.
Papers
More filters
Journal ArticleDOI
Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
Zachary T. Schug,Barrie Peck,Dylan T. Jones,Qifeng Zhang,Shaun E. Grosskurth,Israt S. Alam,Louise Goodwin,Elizabeth Smethurst,Susan M. Mason,Karen Blyth,Lynn McGarry,Daniel James,Emma Shanks,Gabriela Kalna,Rebecca E. Saunders,Ming Jiang,Michael Howell,Francois Lassailly,May Zaw Thin,Bradley Spencer-Dene,Gordon Stamp,Niels J. F. van den Broek,Gillian M. Mackay,Vinay Bulusu,Jurre J. Kamphorst,Saverio Tardito,David P. Strachan,Adrian L. Harris,Eric O. Aboagye,Susan E. Critchlow,Michael J.O. Wakelam,Almut Schulze,Eyal Gottlieb +32 more
TL;DR: A critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment is concluded, indicating a critical role in the growth of cancer cell growth under low-oxygen and lipid-depleted conditions.
Journal ArticleDOI
Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)
Christoph Licht,Stefan Heinen,Mihály Józsi,Ina Löschmann,Rebecca E. Saunders,Stephen J. Perkins,Ruediger Waldherr,Christine Skerka,Michael Kirschfink,Bernd Hoppe,Peter F. Zipfel,Peter F. Zipfel +11 more
TL;DR: Replacement of functional Factor H by fresh frozen plasma was well tolerated, prevented so far disease progression in both patients, and is in the long run expected to preserve kidney function.
Journal ArticleDOI
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer
Elza C. de Bruin,Catherine F. Cowell,Patricia H. Warne,Ming Jiang,Rebecca E. Saunders,Mary Ann Melnick,Scott N. Gettinger,Zenta Walther,Anna Wurtz,Guus J. J. E. Heynen,Daniëlle A.M. Heideman,Jose Javier Gomez-Roman,Almudena García-Castaño,Yixuan Gong,Marc Ladanyi,Harold E. Varmus,René Bernards,Egbert F. Smit,Katerina Politi,Julian Downward +19 more
TL;DR: A subgroup of patients with EG FR-mutant lung adenocarcinoma who might benefit from combination therapy with EGFR and MEK inhibitors are identified.
Journal ArticleDOI
The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models.
Rebecca E. Saunders,Cynthia Abarrategui-Garrido,Véronique Frémeaux-Bacchi,Elena Goicoechea de Jorge,Timothy H.J. Goodship,Margarita López Trascasa,Marina Noris,Isabel Maria Ponce Castro,Giuseppe Remuzzi,Santiago Rodríguez de Córdoba,Pilar Sánchez-Corral,Christine Skerka,Peter F. Zipfel,Stephen J. Perkins +13 more
TL;DR: New aHUS mutations are reported for the complement regulatory proteins Factor H (FH), Factor I (FI), and membrane cofactor protein (MCP) and new mutations or polymorphisms within CFH have been associated with membranoproliferative glomerulonephritis and age‐related macular degeneration.
Journal ArticleDOI
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
Barrie Peck,Barrie Peck,Zachary T. Schug,Qifeng Zhang,Beatrice Dankworth,Dylan T. Jones,Elizabeth Smethurst,Rachana Patel,Susan M. Mason,Ming Jiang,Rebecca E. Saunders,Michael Howell,Richard Mitter,Bradley Spencer-Dene,Gordon Stamp,Lynn McGarry,Daniel James,Emma Shanks,Eric O. Aboagye,Susan E. Critchlow,Hing Y. Leung,Adrian L. Harris,Michael J.O. Wakelam,Eyal Gottlieb,Almut Schulze,Almut Schulze +25 more
TL;DR: The data implicate lipid desaturation as an essential process for cancer cell survival and suggest that targeting SCD could efficiently limit tumour expansion, especially under the metabolically compromised conditions of the tumour microenvironment.