Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
Zachary T. Schug,Barrie Peck,Dylan T. Jones,Qifeng Zhang,Shaun E. Grosskurth,Israt S. Alam,Louise Goodwin,Elizabeth Smethurst,Susan M. Mason,Karen Blyth,Lynn McGarry,Daniel James,Emma Shanks,Gabriela Kalna,Rebecca E. Saunders,Ming Jiang,Michael Howell,Francois Lassailly,May Zaw Thin,Bradley Spencer-Dene,Gordon Stamp,Niels J. F. van den Broek,Gillian M. Mackay,Vinay Bulusu,Jurre J. Kamphorst,Saverio Tardito,David P. Strachan,Adrian L. Harris,Eric O. Aboagye,Susan E. Critchlow,Michael J.O. Wakelam,Almut Schulze,Eyal Gottlieb +32 more
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TLDR
A critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment is concluded, indicating a critical role in the growth of cancer cell growth under low-oxygen and lipid-depleted conditions.About:
This article is published in Cancer Cell.The article was published on 2015-01-12 and is currently open access. It has received 569 citations till now. The article focuses on the topics: ACSS2 & Acetyl—CoA synthetase.read more
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The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
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Fundamentals of cancer metabolism
TL;DR: A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.
Journal ArticleDOI
Metabolic pathways promoting cancer cell survival and growth.
TL;DR: These adaptive mechanisms that promote metabolic reprogramming in cancer and emerging approaches to probe tumour metabolism in vivo are discussed and their potential to expand the metabolic repertoire of malignant cells even further are discussed.
Journal ArticleDOI
Cancer metabolism: a therapeutic perspective
Ubaldo E. Martinez-Outschoorn,Maria Peiris-Pagès,Richard G. Pestell,Federica Sotgia,Federica Sotgia,Michael P. Lisanti +5 more
TL;DR: How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted.
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Mitochondrial TCA cycle metabolites control physiology and disease.
TL;DR: This review summarizes the mechanisms by which the abundance of different TCA cycle metabolites controls cellular function and fate in different contexts and focuses on how these metabolites mediated signaling can affect physiology and disease.
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TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.
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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
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High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
Daniel Pinkel,Daniel Pinkel,Richard Segraves,Damir Sudar,Steven M. Clark,Ian Poole,David Kowbel,Colin Collins,Wen Lin Kuo,Chira Chen,Ye Zhai,Shanaz H. Dairkee,Britt-Marie Ljung,Joe W. Gray,Joe W. Gray,Donna G. Albertson,Donna G. Albertson,Donna G. Albertson +17 more
TL;DR: The implementation of array CGH is demonstrated to be able to measure copy number with high precision in the human genome, and to analyse clinical specimens by obtaining new information on chromosome 20 aberrations in breast cancer.
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