Gabriela Kalna

TL;DR: A critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment is concluded, indicating a critical role in the growth of cancer cell growth under low-oxygen and lipid-depleted conditions.

TL;DR: This work predicted and confirmed that targeting this pathway would render Fh1-deficient cells non-viable, while sparing wild-type Fh2-containing cells, and demonstrated that inhibition of haem oxygenation is synthetically lethal when combined with Fh 1 deficiency.

TL;DR: It is found that RAC1 is required for expansion of the LGR5 intestinal stem cell (ISC) signature, progenitor hyperproliferation, and transformation, and Mechanistically, Rac1-driven ROS and NF-κB signaling mediate these processes.

TL;DR: This study generated Sdhb-ablated kidney mouse cells and used comparative metabolomics and stable-isotope-labelling approaches to identify nutritional requirements and metabolic adaptations to SDH loss and demonstrated that pyruvate carboxylation diverts glucose-derived carbons into aspartate biosynthesis, thus sustaining cell growth.

TL;DR: A physiological medium improves the metabolic fidelity and biological relevance of in vitro cancer models and reveals that breast cancer spheroids grown in Plasmax approximate the metabolic profile of mammary tumors better.