Gillian M. Mackay

TL;DR: It is shown, in a humanized genetically-modified mouse model of pancreatic ductal adenocarcinoma (PDAC), that autophagy’s role in tumour development is intrinsically connected to the status of the tumour suppressor p53, and treatment with hydroxychloroquine significantly accelerates tumour formation in mice containing oncogenic Kras but lacking p53.

TL;DR: A critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment is concluded, indicating a critical role in the growth of cancer cell growth under low-oxygen and lipid-depleted conditions.

TL;DR: It is shown that the mitochondrial gatekeeper pyruvate dehydrogenase (PDH) is a crucial mediator of senescence induced by BRAFV600E, an oncogene commonly mutated in melanoma and other cancers, and a mechanistic relationship between OIS and a key metabolic signalling axis is revealed, which may be exploited therapeutically.

TL;DR: It is concluded that nucleotide synthesis and cancer cell proliferation are supported by serine--rather than glycine--consumption, and therefore exogenous glycine cannot replace serine to supportcancer cell proliferation.

TL;DR: The authors showed that restricting dietary serine and glycine can reduce tumour growth in xenograft and allograft models, and this observation translates into more clinically relevant autochthonous tumours in genetically engineered mouse models of intestinal cancer or lymphoma.