I
Istvan Jona
Researcher at University of Debrecen
Publications - 51
Citations - 2009
Istvan Jona is an academic researcher from University of Debrecen. The author has contributed to research in topics: Ryanodine receptor & Calcium. The author has an hindex of 22, co-authored 51 publications receiving 1934 citations. Previous affiliations of Istvan Jona include State University of New York System & Hungarian Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum.
TL;DR: It is found that at low ATP concentrations (0.5-2 microM) the inhibition of ATPase activity was essentially complete at a CPA concentration of 6-8 nmol/mg protein, indicating stoichiometric reaction of CPA with the Ca2+-ATPase, which suggests that CPA interferes with the ATP-induced conformational changes related to Ca2- transport.
Journal ArticleDOI
Calsequestrin: More than 'only' a luminal Ca2+ buffer inside the sarcoplasmic reticulum
TL;DR: It is shown that, depending on its phosphorylation state, calsequestrin selectively controls the RyR channel activity at 1 mM free luminal [Ca2+], and solely dephosphorylated calsequer regulates Ca2+ release from the SR.
Journal ArticleDOI
Sarcolipin, the "proteolipid" of skeletal muscle sarcoplasmic reticulum, is a unique, amphipathic, 31-residue peptide.
Alicja Wawrzynow,Janet L. Theibert,C. M. Murphy,Istvan Jona,Anthony Martonosi,John H. Collins +5 more
TL;DR: The name sarcolipin is proposed for this small protein, to signify its lipid-like solubility and association with the sarcoplasmic reticulum of rabbit skeletal muscle, and the molecular weight calculated from the sequence agrees with that measured by fast atom bombardment mass spectrometry, showing that sarcolippin contains no attached fatty acyl or other prosthetic groups.
Journal ArticleDOI
Effects of Dantrolene on Steps of Excitation-Contraction Coupling in Mammalian Skeletal Muscle Fibers
Péter Szentesi,Claude Collet,Sándor Sárközi,Csaba Szegedi,Istvan Jona,Vincent Jacquemond,László Kovács,László Csernoch +7 more
TL;DR: Dantrolene was found to suppress the depolarization-induced elevation in intracellular calcium concentration ([Ca2+]i) by inhibiting the release of calcium from the SR by binding on the SR membrane, but be distinct from the purified RYR itself.
Journal ArticleDOI
The effect of ionomycin on calcium fluxes in sarcoplasmic reticulum vesicles and liposomes.
TL;DR: Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M.