Istvan Jona

TL;DR: It is found that at low ATP concentrations (0.5-2 microM) the inhibition of ATPase activity was essentially complete at a CPA concentration of 6-8 nmol/mg protein, indicating stoichiometric reaction of CPA with the Ca2+-ATPase, which suggests that CPA interferes with the ATP-induced conformational changes related to Ca2- transport.

TL;DR: It is shown that, depending on its phosphorylation state, calsequestrin selectively controls the RyR channel activity at 1 mM free luminal [Ca2+], and solely dephosphorylated calsequer regulates Ca2+ release from the SR.

TL;DR: The name sarcolipin is proposed for this small protein, to signify its lipid-like solubility and association with the sarcoplasmic reticulum of rabbit skeletal muscle, and the molecular weight calculated from the sequence agrees with that measured by fast atom bombardment mass spectrometry, showing that sarcolippin contains no attached fatty acyl or other prosthetic groups.

TL;DR: Dantrolene was found to suppress the depolarization-induced elevation in intracellular calcium concentration ([Ca2+]i) by inhibiting the release of calcium from the SR by binding on the SR membrane, but be distinct from the purified RYR itself.

TL;DR: Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M.