Ivan Topisirovic

TL;DR: The investigations described here illustrate the potential of the Z protein as a promising target for therapy and the prospects of theZ-reactive compounds to prevent arenavirus dissemination.

TL;DR: It is demonstrated that ERα orchestrates proliferation and metabolism to promote the neoplastic growth of PCa cells in mice models of aggressive PCa driven by MYC overexpression or deletion of PTEN.

TL;DR: It is shown that the effect of exposure of several transformed cell lines to metformin varies with carbon source, and it is suggested that meetingformin-induced increase in glycolysis attenuates the antiproliferative effects of the compound.

TL;DR: This study uncovers a mechanism for regulating long-lasting synaptic plasticity and spatial memory formation and reveals an unexpected divergent role of FXR1P among Fragile X proteins in brain plasticity.

TL;DR: It is shown that the endo-lysosomal system undergoes an expansion in volume and holding capacity during phagocyte activation within 2 h of lipopolysaccharides (LPS) stimulation, and a hitherto unappreciated mechanism of acute organelle expansion via mTOR Complex 1 (mTORC1)-dependent increase in translation, which appears to be mediated by both S6Ks and 4E-BPs.