Ivo Lieberam

TL;DR: It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo.

TL;DR: It is shown that motor axon growth and guidance are impaired in the absence of Sema3A-Npn-1 signaling, and that Sema2F-NPN-2 signaling guides the axons of a medial subset of LMC neurons to the ventral limb, but plays no major role in regulating their fasciculation.

TL;DR: A novel population of glutamatergic interneurons located adjacent to the ventral commissure from cervical to midlumbar spinal cord levels are described, which suggest that they are candidate locomotor rhythm-generating interneuron networks.

TL;DR: It is shown that CCL17 expression in mice is found in activated Langerhans cells and mature DCs located in various lymphoid and nonlymphoid organs, and is up-regulated after stimulation with Toll-like receptor ligands, indicating that CCR17 production is a hallmark of local DC stimulation in peripheral organs but is absent from the spleen as a filter of blood-borne antigens.

TL;DR: It is shown that the chemokine receptor Cxcr4 is expressed on the axons of vMNs as they follow their ventral trajectory, whereas its ligand, Cxcl12, is expressed by mesenchymal cells surrounding the ventral neural tube.