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Izaskun Elezgarai
Researcher at University of the Basque Country
Publications - 42
Citations - 1727
Izaskun Elezgarai is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Neurotransmission & Cannabinoid receptor. The author has an hindex of 19, co-authored 39 publications receiving 1405 citations.
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Journal ArticleDOI
A cannabinoid link between mitochondria and memory
Etienne Hebert-Chatelain,Etienne Hebert-Chatelain,Etienne Hebert-Chatelain,Tifany Desprez,Tifany Desprez,Roman Serrat,Roman Serrat,Luigi Bellocchio,Luigi Bellocchio,Luigi Bellocchio,Edgar Soria-Gomez,Edgar Soria-Gomez,Arnau Busquets-Garcia,Arnau Busquets-Garcia,Antonio C Pagano Zottola,Antonio C Pagano Zottola,Anna Delamarre,Anna Delamarre,Astrid Cannich,Astrid Cannich,Peggy Vincent,Peggy Vincent,Marjorie Varilh,Marjorie Varilh,Laurie M. Robin,Laurie M. Robin,Geoffrey Terral,Geoffrey Terral,M. Dolores García-Fernández,Michelangelo Colavita,Michelangelo Colavita,Michelangelo Colavita,Wilfrid Mazier,Wilfrid Mazier,Filippo Drago,Nagore Puente,Leire Reguero,Izaskun Elezgarai,Jean-William Dupuy,Daniela Cota,Daniela Cota,Maria-Luz Lopez-Rodriguez,Gabriel Barreda-Gómez,Federico Massa,Federico Massa,Pedro Grandes,Pedro Grandes,Giovanni Benard,Giovanni Benard,Giovanni Marsicano,Giovanni Marsicano +50 more
TL;DR: It is shown that acute cannabinoid-induced memory impairment in mice requires activation of hippocampal mtCB1 receptors, and this data reveal that bioenergetic processes are primary acute regulators of cognitive functions.
Journal ArticleDOI
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
Mathieu Lafourcade,Izaskun Elezgarai,Susana Mato,Susana Mato,Yamina Bakiri,Pedro Grandes,Olivier J. Manzoni +6 more
TL;DR: The data show that the endocannabinoid -retrograde signaling plays a prominent role in long-term synaptic plasticity at the excitatory synapses of the PFC.
Journal ArticleDOI
Targeting the endocannabinoid system: future therapeutic strategies
Oier Aizpurua-Olaizola,Izaskun Elezgarai,Irantzu Rico-Barrio,Iratxe Zarandona,Nestor Etxebarria,Aresatz Usobiaga +5 more
TL;DR: This review of the latest studies regarding the role of the ECS and the drugs that target it highlights the creation of a cannabinoid-receptor interaction matrix (CRIM) and the use of metabolomics toward the development of improved and more specific drugs for each relevant disease.
Posted Content
Targeting the endocannabinoid system: future therapeutic strategies
Oier Aizpurua-Olaizola,Izaskun Elezgarai,Irantzu Rico-Barrio,Iratxe Zarandona,Nestor Etxebarria,Aresatz Usobiaga +5 more
TL;DR: In this paper, the authors highlight the latest studies regarding the role of the endocannabinoid system and the drugs that target it, with a particular focus on the basis for the discovery of new cannabinoid-based drugs.
Journal ArticleDOI
Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration.
Juan Mendizabal-Zubiaga,Su Melser,Su Melser,Giovanni Benard,Giovanni Benard,Almudena Ramos,Leire Reguero,Sergio Arrabal,Izaskun Elezgarai,Inmaculada Gerrikagoitia,Juan Suárez,Fernando Rodríguez de Fonseca,Nagore Puente,Giovanni Marsicano,Giovanni Marsicano,Pedro Grandes,Pedro Grandes +16 more
TL;DR: In conclusion, CB1 receptors in skeletal and myocardial muscles are predominantly localized in mitochondria, and the activation of mtCB1 receptors may participate in the mitochondrial regulation of the oxidative activity probably through the relevant enzymes implicated in the pyruvate metabolism, a main substrate for TCA activity.