Marjorie Varilh

TL;DR: It is shown that acute cannabinoid-induced memory impairment in mice requires activation of hippocampal mtCB1 receptors, and this data reveal that bioenergetic processes are primary acute regulators of cognitive functions.

TL;DR: It is shown that astroglial CB1 receptors are key determinants of object recognition memory by determining the availability of D-serine at hippocampal synapses and elevating D-Serine levels fully rescued LTP and memory impairments of GFAP-CB1-KO mice.

TL;DR: In mice, persistent activation of mitochondrial cannabinoid receptors in astroglia impairs cellular glucose metabolism and lactate production, leading to an increase in redox stress in neurons and altered behavioural responses.

TL;DR: Test in mice the potential therapeutic use of pregnenolone against acute psychotic-like effects of Δ9-tetrahydrocannabinol, the main psychoactive component of cannabis found that it blocks a wide spectrum of THC-induced endophenotypes typically associated with psychotic- like states, including impairments in cognitive functions, somatosensory gating and social interaction.

TL;DR: S sensory preconditioning procedures show that type 1 cannabinoid receptors (CB1R) in hippocampal GABAergic neurons are necessary and sufficient for mediated but not direct learning, and CB1R-dependent control of inhibitory hippocampal neurotransmission mediates incidental associations.