J
J. Alexandra Rowe
Researcher at University of Edinburgh
Publications - 64
Citations - 4098
J. Alexandra Rowe is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 32, co-authored 64 publications receiving 3708 citations. Previous affiliations of J. Alexandra Rowe include John Radcliffe Hospital & University of Maryland, Baltimore.
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Journal ArticleDOI
Adhesion of Plasmodium falciparum -infected erythrocytes to human cells: molecular mechanisms and therapeutic implications
TL;DR: Further research is needed to realise the untapped potential of antiadhesion adjunctive therapies, which could revolutionise the treatment of severe malaria and reduce the high mortality rate of the disease.
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Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
J. Alexandra Rowe,Ian Handel,Mahamadou A. Thera,Anne-Marie Deans,Kirsten E. Lyke,Abdoulaye K. Kone,Dapa A. Diallo,Ahmed Raza,Oscar Kai,Kevin Marsh,Christopher V. Plowe,Ogobara K. Doumbo,Joann M. Moulds +12 more
TL;DR: In a matched case-control study of 567 Malian children, the authors found that group O was present in only 21% of severe malaria cases compared with 44-45% of uncomplicated malaria controls and healthy controls.
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A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.
Ian A. Cockburn,Margaret J. Mackinnon,Angela O’Donnell,Stephen J. Allen,Joann M. Moulds,Moses Baisor,Moses J. Bockarie,John C. Reeder,J. Alexandra Rowe +8 more
TL;DR: CR1 is identified as a new malaria resistance gene and provided compelling evidence that rosetting is an important parasite virulence phenotype that should be a target for drug and vaccine development.
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Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
Helen M. Kyriacou,Graham N. Stone,Richard Challis,Arif Ahmed Raza,Kirsten E. Lyke,Mahamadou A. Thera,Abdoulaye K. Kone,Ogobara K. Doumbo,Christopher V. Plowe,J. Alexandra Rowe +9 more
TL;DR: It is suggested that var genes with DBLα1-like domains (Group A or B/A) may be implicated in the pathogenesis of cerebral malaria, while var genes in other groups promote less virulent malaria infections.
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A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.
Antoine Claessens,Yvonne Adams,Ashfaq Ghumra,Gabriella Lindergard,Caitlin C. Buchan,Cheryl Andisi,Peter C. Bull,Sachel Mok,Archna P. Gupta,Christian W. Wang,Louise Turner,Mònica Arman,Ahmed Raza,Zbynek Bozdech,J. Alexandra Rowe +14 more
TL;DR: A binding phenotype for virulence-associated group A P. falciparum erythrocyte membrane protein 1 variants is described and targets for interventions to treat or prevent cerebral malaria are identified.