J
Joann M. Moulds
Researcher at Drexel University
Publications - 84
Citations - 4897
Joann M. Moulds is an academic researcher from Drexel University. The author has contributed to research in topics: Complement receptor 1 & Plasmodium falciparum. The author has an hindex of 36, co-authored 84 publications receiving 4662 citations. Previous affiliations of Joann M. Moulds include University of Texas Health Science Center at Houston & University of Ulm.
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Journal ArticleDOI
P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
TL;DR: A new adhesive function for Pf EMP1 is described and the possibility that CR1 polymorphisms in Africans that influence the interaction between erythrocytes and PfEMP1 may protect against severe malaria is raised.
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Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
J. Alexandra Rowe,Ian Handel,Mahamadou A. Thera,Anne-Marie Deans,Kirsten E. Lyke,Abdoulaye K. Kone,Dapa A. Diallo,Ahmed Raza,Oscar Kai,Kevin Marsh,Christopher V. Plowe,Ogobara K. Doumbo,Joann M. Moulds +12 more
TL;DR: In a matched case-control study of 567 Malian children, the authors found that group O was present in only 21% of severe malaria cases compared with 44-45% of uncomplicated malaria controls and healthy controls.
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Systemic lupus erythematosus in three ethnic groups: III A comparison of characteristics early in the natural history of the LUMINA cohort:
Graciela S. Alarcón,Alan Friedman,Karin V. Straaton,Joann M. Moulds,Jeffrey R. Lisse,Holly M. Bastian,Gerald McGwin,Alfred A. Bartolucci,Jeffrey M. Roseman,John D. Reveille +9 more
TL;DR: H and AA patients have more active SLE, at an earlier age of onset, and a lessavorable socioeconomic-demographic structure (worse among the H than AA) which predispose them to a less favorable natural history.
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A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.
Ian A. Cockburn,Margaret J. Mackinnon,Angela O’Donnell,Stephen J. Allen,Joann M. Moulds,Moses Baisor,Moses J. Bockarie,John C. Reeder,J. Alexandra Rowe +8 more
TL;DR: CR1 is identified as a new malaria resistance gene and provided compelling evidence that rosetting is an important parasite virulence phenotype that should be a target for drug and vaccine development.
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Systemic lupus erythematosus in three ethnic groups: I. The effects of HLA class II, C4, and CR1 alleles, socioeconomic factors, and ethnicity at disease onset
John D. Reveille,Joann M. Moulds,Chul Ahn,Alan Friedman,Bruce A. Baethge,Jeffrey M. Roseman,Karin V. Straaton,Graciela S. Alarcón +7 more
TL;DR: Both genetic and socioeconomic determinants, as well as other factors associated with Hispanic and African-American ethnicity, affect the presentation of SLE.