J. Craig Venter

TL;DR: The authors study the interplay between the microbiome and faecal and blood metabolome, and how the microbiome interacts in the dialogue between these metabolic compartments, identifying a key role for microbial functions and underscoring their relevance for microbiome therapeutic strategies.

TL;DR: A whole-genome sequencing study of common, low-frequency and rare variants to associate genetic variations with blood metabolite levels using comprehensive metabolite profiling in 1,960 adults highlights the importance of heterozygous rare variants in determining abnormal blood metabolic phenotypes in adults.

TL;DR: This work reports on the sequencing of 10,545 human genomes at 30×–40× coverage with an emphasis on quality metrics and novel variant and sequence discovery and concludes that high-coverage genome sequencing provides accurate detail on human variation for discovery and clinical applications.

TL;DR: The characterization of the blood virome is important for the safety of blood-derived transfusion products, and for the identification of emerging pathogens, and non-human sequence data from whole-genome sequencing of blood from 8,240 individuals were explored.

TL;DR: It is found that obesity results in profound perturbation of the metabolome; nearly a third of the assayed metabolites associated with changes in BMI are associated withChanges in BMI.