K
Kasper Lage
Researcher at Broad Institute
Publications - 5
Citations - 153
Kasper Lage is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 4, co-authored 5 publications receiving 52 citations. Previous affiliations of Kasper Lage include Massachusetts Institute of Technology & University of Copenhagen.
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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases
Elle M. Weeks,Jacob C. Ulirsch,Jacob C. Ulirsch,Nathan Cheng,Brian L. Trippe,Rebecca S. Fine,Jenkai Miao,Jenkai Miao,Tejal A. Patwardhan,Tejal A. Patwardhan,Masahiro Kanai,Joseph Nasser,Charles P. Fulco,Charles P. Fulco,Katherine Tashman,François Aguet,Taibo Li,Taibo Li,Jose Ordovas-Montanes,Christopher Smillie,Christopher Smillie,Moshe Biton,Moshe Biton,Alex K. Shalek,Ashwin N. Ananthakrishnan,Ramnik J. Xavier,Aviv Regev,Rajat M. Gupta,Rajat M. Gupta,Rajat M. Gupta,Kasper Lage,Kristin G. Ardlie,Kristin G. Ardlie,Joel N. Hirschhorn,Eric S. Lander,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz,Hilary K. Finucane +39 more
TL;DR: A new method to identify the causal genes by integrating GWAS summary statistics with gene expression, biological pathway, and predicted protein-protein interaction data is introduced, demonstrating that a polygenic approach is a powerful tool for gene prioritization and, in combination with locus-specific signal, improves upon existing methods.
Journal ArticleDOI
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML
Zuzana Tothova,Zuzana Tothova,Anne-Laure Valton,Rebecca A. Gorelov,Mounica Vallurupalli,Mounica Vallurupalli,John M. Krill-Burger,Amie Holmes,Catherine C. Landers,J. Erika Haydu,Edyta Malolepsza,Christina R. Hartigan,Melanie Donahue,Katerina D. Popova,Sebastian Koochaki,Sergey V. Venev,Jeanne F Rivera,Edwin Chen,Kasper Lage,Monica Schenone,Alan D. D'Andrea,Steven A. Carr,Elizabeth A. Morgan,Job Dekker,Job Dekker,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +27 more
TL;DR: In this paper, the cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation, and DNA damage repair and replication are identified as genetic dependencies in cohesIN-mutant cells.
Journal ArticleDOI
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor
Blandine Roux,Camille Vaganay,Jesse D. Vargas,Gabriela Alexe,Gabriela Alexe,Chaïma Benaksas,Bryann Pardieu,Nina Fenouille,Jana M. Ellegast,Jana M. Ellegast,Edyta Malolepsza,Frank Ling,Gaetano Sodaro,Linda Ross,Linda Ross,Yana Pikman,Yana Pikman,Amy Saur Conway,Amy Saur Conway,Yangzhong Tang,Tony Wu,Daniel Anderson,Ronan Le Moigne,Han-Jie Zhou,Frederic Luciano,Christina R. Hartigan,Ilene Galinsky,Daniel J. DeAngelo,Richard Stone,Patrick Auberger,Monica Schenone,Steven A. Carr,Josée Guirouilh-Barbat,Bernard S. Lopez,Mehdi Khaled,Kasper Lage,Olivier Hermine,Michael T. Hemann,Alexandre Puissant,Kimberly Stegmaier,Kimberly Stegmaier,Lina Benajiba +41 more
TL;DR: In this paper, the authors identified the AAA-ATPase valosin-containing protein (VCP) as a top stress-related vulnerability in acute myeloid leukemia (AML).
Posted ContentDOI
The architecture of brain co-expression reveals the brain-wide basis of disease susceptibility
Hartl C,Hartl C,Gokul Ramaswami,William G Pembroke,Muller S,Greta Pintacuda,Ashis Saha,Princy Parsana,Alexis Battle,Kasper Lage,Kasper Lage,Daniel H. Geschwind +11 more
TL;DR: This work identifies enrichment of neuropsychiatric disease risk variants in brain wide and multi-regional modules, consistent with their broad impact on cell classes, and highlights specific roles in neuronal proliferation and activity-dependent processes.
Posted ContentDOI
Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes
Hoang T. Nguyen,Amanda Dobbyn,Alexander W. Charney,Julien Bryois,April Kim,Mcfadden W,Nathan G. Skene,Huckins Lm,Wenhui Wang,Douglas M. Ruderfer,Xinyi Xu,Menachem Fromer,Shaun Purcell,Kasper Lage,Matthijs Verhage,August B. Smit,Jens Hjerling-Leffler,Joseph D. Buxbaum,Dalila Pinto,Xin He,P.F. Sullivan,E Stahl,E Stahl +22 more
TL;DR: A Bayesian statistical framework is presented, termed gTADA, that integrates gene-set membership information with gene-level de novo and rare inherited case-control counts, to prioritize risk genes with excess rare variant burden within enriched gene sets for epilepsy and EPI.