J. Russell Geyer

TL;DR: VCPplus XRT is a superior adjuvant combination compared with 8-in-1 chemotherapy plus XRT, and for patients with M0 tumors, residual tumor bulk (not extent of resection) is a predictor for PFS.

TL;DR: In this paper, the authors identify trends over the past two decades in the pattern of deaths attributable to pediatric CCCs, examining counts and rates of CCC-attributed deaths by cause and age (infancy: <1 year old, childhood: 1-9 years old, adolescence or young adulthood: 10-24 years old) at the time of death, and to determine the average number of children living within the last 6 months of their lives.

TL;DR: Global DNA methylation profiles were significantly associated with the p.Lys27Met alteration, regardless of the mutant histone H3 variant and irrespective of tumor location, supporting the role of this substitution in driving the epigenetic phenotype.

TL;DR: Intensified induction chemotherapy resulted in a high response rate of malignant brain tumors in infants and survival was comparable to that of previous studies, and most patients who survived did not receive radiation therapy.

TL;DR: The pattern of predominantly local relapse and the important influence of residual tumor or the extent of resection on PFS duration confirms a prevailing impression that local disease control is the major factor in the prediction of outcome of ependymoma.