Liliana Goumnerova

TL;DR: It is demonstrated that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours, atypical teratoid/rhabdoid tumours (AT/RTs) and malignant gliomas, and it is shown that the clinical outcome of children with medullOBlastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis.

TL;DR: It is shown that a previously unidentified molecular subgroup, characterized genetically by c-MYC copy number gains and transcriptionally by enrichment of photoreceptor pathways and increased miR-183∼96∼182 expression, is associated with significantly lower rates of event-free and overall survivals.

TL;DR: This study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.

TL;DR: Global DNA methylation profiles were significantly associated with the p.Lys27Met alteration, regardless of the mutant histone H3 variant and irrespective of tumor location, supporting the role of this substitution in driving the epigenetic phenotype.

TL;DR: This intensive multimodality regimen has resulted in a significant improvement in time to progression and overall survival for patients with this previously poor-prognosis CNS ATRT.