H
Hamid Nikbakht
Researcher at McGill University
Publications - 24
Citations - 2553
Hamid Nikbakht is an academic researcher from McGill University. The author has contributed to research in topics: Random subspace method & DNA methylation. The author has an hindex of 14, co-authored 24 publications receiving 1758 citations. Previous affiliations of Hamid Nikbakht include Concordia University Wisconsin & Concordia University.
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Journal ArticleDOI
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
Alan Mackay,Anna Burford,Diana Carvalho,Elisa Izquierdo,Janat Fazal-Salom,Kathryn R. Taylor,Kathryn R. Taylor,Lynn Bjerke,Matthew Clarke,Mara Vinci,Meera Nandhabalan,Sara Temelso,Sergey Popov,Sergey Popov,Valeria Molinari,Pichai Raman,Angela J. Waanders,Harry J. Han,Saumya Gupta,Lynley V. Marshall,Stergios Zacharoulis,Sucheta Vaidya,Henry Mandeville,Leslie R. Bridges,Andrew J. Martin,Safa Al-Sarraj,Christopher Chandler,Ho Keung Ng,Xingang Li,Kun Mu,Saoussen Trabelsi,Dorra H'mida-Ben Brahim,Alexei N. Kisljakov,Dmitry M. Konovalov,Andrew S. Moore,Angel M. Carcaboso,Mariona Suñol,Carmen Torres,Ofelia Cruz,Jaume Mora,Ludmila I. Shats,João Norberto Stávale,Lucas Tadeu Bidinotto,Rui Manuel Reis,Natacha Entz-Werle,Michael A. Farrell,Jane Cryan,Darach Crimmins,John Caird,Jane Pears,Michelle Monje,Marie-Anne Debily,David Castel,Jacques Grill,Cynthia Hawkins,Hamid Nikbakht,Nada Jabado,Suzanne J. Baker,Stefan M. Pfister,Stefan M. Pfister,David T.W. Jones,Maryam Fouladi,André O. von Bueren,André O. von Bueren,Michael Baudis,Adam C. Resnick,Chris Jones +66 more
TL;DR: Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct, and co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H 3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H2.1K 27M are identified.
Journal ArticleDOI
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
Adam M. Fontebasso,Simon Papillon-Cavanagh,Jeremy Schwartzentruber,Hamid Nikbakht,Noha Gerges,Pierre Fiset,Denise Bechet,Damien Faury,Nicolas De Jay,Lori A. Ramkissoon,Aoife Corcoran,David T.W. Jones,Dominik Sturm,Pascal Johann,Tadanori Tomita,Stewart Goldman,Mahmoud Nagib,Anne Bendel,Liliana Goumnerova,Daniel C. Bowers,Jeffrey R. Leonard,Joshua B. Rubin,Tord D. Alden,Samuel R. Browd,J. Russell Geyer,Sarah Leary,George I. Jallo,Kenneth J. Cohen,Nalin Gupta,Michael D. Prados,Anne Sophie Carret,Benjamin Ellezam,Louis Crevier,Almos Klekner,László Bognár,Peter Hauser,Miklós Garami,John S. Myseros,Zhifeng Dong,Peter M. Siegel,Hayley Malkin,Azra H. Ligon,Steffen Albrecht,Stefan M. Pfister,Keith L. Ligon,Jacek Majewski,Nada Jabado,Mark W. Kieran +47 more
TL;DR: Global DNA methylation profiles were significantly associated with the p.Lys27Met alteration, regardless of the mutant histone H3 variant and irrespective of tumor location, supporting the role of this substitution in driving the epigenetic phenotype.
Journal ArticleDOI
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
Daniel N. Weinberg,Simon Papillon-Cavanagh,Haifen Chen,Yuan Yue,Xiao Chen,Kartik N. Rajagopalan,Cynthia Horth,John T. McGuire,Xinjing Xu,Hamid Nikbakht,Agata E. Lemiesz,Dylan M. Marchione,Matthew R. Marunde,Matthew J. Meiners,Marcus A. Cheek,Michael-Christopher Keogh,Eric Bareke,Anissa Djedid,Ashot S. Harutyunyan,Nada Jabado,Benjamin A. Garcia,Haitao Li,C. David Allis,Jacek Majewski,Chao Lu +24 more
TL;DR: A trans-chromatin regulatory pathway is revealed that connects aberrant intergenic CpG methylation to human neoplastic and developmental overgrowth and NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at intergenic regions.
Journal ArticleDOI
Next-generation DNA barcoding: using next-generation sequencing to enhance and accelerate DNA barcode capture from single specimens.
Shadi Shokralla,Shadi Shokralla,Joel F. Gibson,Hamid Nikbakht,Daniel H. Janzen,Winnie Hallwachs,Mehrdad Hajibabaei +6 more
TL;DR: The potential application of next‐generation sequencing platforms for parallel acquisition of DNA barcode sequences from hundreds of specimens simultaneously is demonstrated and Wolbachia, nontarget species, and heteroplasmic sequences are detected.
Journal ArticleDOI
Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
Hamid Nikbakht,Eshini Panditharatna,Leonie G. Mikael,Rui Li,Tenzin Gayden,Matthew M. Osmond,Cheng-Ying Ho,Madhuri Kambhampati,Eugene Hwang,Damien Faury,Alan Siu,Simon Papillon-Cavanagh,Denise Bechet,Keith L. Ligon,Benjamin Ellezam,Wendy J. Ingram,Caedyn Stinson,Andrew S. Moore,Katherine E. Warren,Jason Karamchandani,Roger J. Packer,Nada Jabado,Jacek Majewski,Javad Nazarian +23 more
TL;DR: The spatial and temporal homogeneity of main driver mutations in DIPG implies they will be captured by limited biopsies and emphasizes the need to develop therapies specifically targeting obligate oncohistone partnerships.