J
J. Scott Lauritzen
Researcher at Howard Hughes Medical Institute
Publications - 27
Citations - 1614
J. Scott Lauritzen is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Mushroom bodies & Concept learning. The author has an hindex of 14, co-authored 27 publications receiving 1062 citations. Previous affiliations of J. Scott Lauritzen include Vision-Sciences, Inc. & University of Texas at Austin.
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Journal ArticleDOI
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster.
Zhihao Zheng,J. Scott Lauritzen,Eric Perlman,Camenzind G. Robinson,Matthew Nichols,Daniel E. Milkie,O. N. Torrens,J.H. Price,Corey B. Fisher,Nadiya Sharifi,Steven A. Calle-Schuler,Lucia Kmecova,Iqbal J. Ali,Bill Karsh,Eric T. Trautman,John A. Bogovic,Philipp Hanslovsky,Gregory S.X.E. Jefferis,Gregory S.X.E. Jefferis,Michael Kazhdan,Khaled Khairy,Stephan Saalfeld,Richard D. Fetter,Davi D. Bock +23 more
TL;DR: Recon reconstructions of the entire brain of an adult female fly show that this freely available EM volume supports mapping of brain-spanning circuits, which will significantly accelerate Drosophila neuroscience.
Posted ContentDOI
A Complete Electron Microscopy Volume Of The Brain Of Adult Drosophila melanogaster
Zhihao Zheng,J. Scott Lauritzen,Eric Perlman,Camenzind G. Robinson,Matthew Nichols,Daniel E. Milkie,O. N. Torrens,J.H. Price,Corey B. Fisher,Nadiya Sharifi,Steven A. Calle-Schuler,Lucia Kmecova,Iqbal J. Ali,Bill Karsh,Eric T. Trautman,John A. Bogovic,Philipp Hanslovsky,Gregory S.X.E. Jefferis,Michael Kazhdan,Khaled Khairy,Stephan Saalfeld,Richard D. Fetter,Davi D. Bock +22 more
TL;DR: A custom high-throughput EM platform was developed and the entire adult fruit fly brain was imaged, using electron microscopy, enabling brain-spanning mapping of neuronal circuits at the synaptic level and finding that axonal arbors providing input to the MB calyx are more tightly clustered than previously indicated by light-level data.
Journal ArticleDOI
Integration of Parallel Opposing Memories Underlies Memory Extinction.
Johannes Felsenberg,Pedro F. Jacob,Thomas Walker,Oliver Barnstedt,Amelia J. Edmondson-Stait,Markus W. Pleijzier,Nils Otto,Nils Otto,Philipp Schlegel,Nadiya Sharifi,Emmanuel Perisse,Carlas Smith,J. Scott Lauritzen,Marta Costa,Gregory S.X.E. Jefferis,Gregory S.X.E. Jefferis,Davi D. Bock,Scott Waddell +17 more
TL;DR: It is shown that extinction of aversive memories in Drosophila requires specific dopaminergic neurons, which indicate that omission of punishment is remembered as a positive experience, and extinction-evoked plasticity in a pair of neurons neutralizes the potentiated odor response imposed in the network by aversive learning.
Journal ArticleDOI
Removing the Frontal Lobes The Effects of Engaging Executive Functions on Perceptual Category Learning
TL;DR: Findings demonstrate the paradoxical situation in which learning can be improved under sequential-task conditions and have important implications for training, decision making, and understanding interactive memory systems.
Journal ArticleDOI
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila
Sercan Sayin,Jean-Francois De Backer,K.P. Siju,Marina E. Wosniack,Marina E. Wosniack,Laurence P. Lewis,Lisa-Marie Frisch,Benedikt Gansen,Philipp Schlegel,Amelia J. Edmondson-Stait,Nadiya Sharifi,Corey B. Fisher,Steven A. Calle-Schuler,J. Scott Lauritzen,Davi D. Bock,Marta Costa,Gregory S.X.E. Jefferis,Gregory S.X.E. Jefferis,Julijana Gjorgjieva,Julijana Gjorgjieva,Ilona C. Grunwald Kadow,Ilona C. Grunwald Kadow +21 more
TL;DR: Using a single fly treadmill, it is shown that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience.