Jacob D. Eccles

TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

TL;DR: The contribution of S1R to the restraint of the inflammatory response is revealed and this work identifies sigma-1 receptor (S1R) as an essential inhibitor of cytokine production in a preclinical model of septic shock.

TL;DR: Lymphatic endothelial cells (LECs) serve as an antigen reservoir for CD4 T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 T- cell tolerance via LAG-3.

TL;DR: The lower airways of children with severe asthma display a dominant TH1 signature and atypical cytokine profiles that link to allergic status and deviate from established paradigms and warrant further assessment of the pathogenicity of TH1 cells in patients withsevere asthma.

TL;DR: The ability of lymphatic endothelial cells to alter immune responses under steady-state or inflammatory conditions is explored, and the therapeutic potential of bypassing lymphatichelial cell-induced tolerance to enhance cancer immunotherapy is discussed.