J
Jacques de Blic
Researcher at Necker-Enfants Malades Hospital
Publications - 135
Citations - 6248
Jacques de Blic is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Asthma & Pulmonary alveolar proteinosis. The author has an hindex of 47, co-authored 133 publications receiving 5527 citations. Previous affiliations of Jacques de Blic include University of Paris & Claude Bernard University Lyon 1.
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Journal ArticleDOI
CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs
Anne-Christine Merveille,Erica E. Davis,Anita Becker-Heck,Anita Becker-Heck,Marie Legendre,Israel Amirav,Géraldine Bataille,John W. Belmont,Nicole Beydon,Frédéric Billen,Annick Clement,Cécile Clercx,André Coste,Rachelle H. Crosbie,Jacques de Blic,Stephane Deleuze,Philippe Duquesnoy,Denise Escalier,Estelle Escudier,Manfred Fliegauf,Judith Horvath,Kent L. Hill,Mark Jorissen,Jocelyne Just,Andreas Kispert,Mark Lathrop,Niki T. Loges,June K. Marthin,Yukihide Momozawa,Guy Montantin,Kim G. Nielsen,H. Olbrich,Jean-François Papon,Isabelle Rayet,Gilles Roger,Miriam Schmidts,Henrique Tenreiro,Jeffrey A. Towbin,Diana Zelenika,Hanswalter Zentgraf,Michel Georges,Anne-Sophie Lequarré,Nicholas Katsanis,Heymut Omran,Serge Amselem +44 more
TL;DR: It is found that loss-of-function mutations in the human ortholog underlie a substantial fraction of PCD cases with axonemal disorganization and abnormal ciliary beating.
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Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients.
Pierre Quartier,Marianne Debré,Jacques de Blic,Rodolphe de Sauverzac,Natacha Sayegh,Nada Jabado,Elie Haddad,Stéphane Blanche,Jean-Laurent Casanova,C. I. Edvard Smith,Françoise Le Deist,Geneviève de Saint Basile,Alain Fischer +12 more
TL;DR: Early IVIg replacement therapy achieving residual IgG levels >500 mg/dL is effective in preventing severe acute bacterial infections and pulmonary insufficiency and more intensive therapy may be required to fully prevent the onset of bronchiectasis, chronic sinusitis, and nonbacterial infections, particularly enteroviral infections, in all cases.
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DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis.
Ludovic Tailleux,Nhan Pham-Thi,Anne Bergeron-Lafaurie,Jean-Louis Herrmann,Patricia Charles,Olivier Schwartz,Pierre Scheinmann,Philippe H. Lagrange,Jacques de Blic,Abdellatif Tazi,Brigitte Gicquel,Olivier Neyrolles,Olivier Neyrolles +12 more
TL;DR: DC-SIGN induction in alveolar Mφs may have important consequences on lung colonization by the tubercle bacillus, and on pulmonary inflammatory and immune responses in the infected host, as well as evidence for an important role of DC-SIGN during TB in humans.
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European protocols for the diagnosis and initial treatment of interstitial lung disease in children
Andrew Bush,Steve Cunningham,Jacques de Blic,Angelo Barbato,Annick Clement,Ralph Epaud,Meike Hengst,Nural Kiper,Andrew G. Nicholson,Martin Wetzke,Deborah Snijders,Nicolaus Schwerk,Matthias Griese +12 more
TL;DR: Proposals for a staged investigation of chILD, starting from when the condition is suspected to defining the diagnosis, using pathways dependent on the clinical condition and the degree of illness of the child are reported.
Journal ArticleDOI
Loss-of-Function Mutations in LRRC6, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms, Cause Primary Ciliary Dyskinesia
Esther Kott,Philippe Duquesnoy,Bruno Copin,Marie Legendre,Florence Dastot-Le Moal,Guy Montantin,Ludovic Jeanson,Aline Tamalet,Jean-François Papon,Jean-Pierre Siffroi,Nathalie Rives,Valérie Mitchell,Jacques de Blic,André Coste,Annick Clement,Denise Escalier,Aminata Touré,Estelle Escudier,Serge Amselem +18 more
TL;DR: The evolutionarily conserved LRRC6 emerges as an additional player in DA assembly, a process that is essential for proper axoneme building and that appears to be much more complex than was previously thought.